| Cat. No. |
Product Name |
Information |
| PC-45537 |
Erdafitinib
FGFR inhibitor
|
Erdafitinib (JNJ-42756493) is a highly potent and selective, small-molecule inhibitor of FGFR family with IC50s of 1.2/2.5/3/5.7 nM for FGFR1/2/3/4. |
| PC-42406 |
FGF-401
FGFR4 inhibitor
|
FGF-401 (NVP-FGF401, Roblitinib, FGF401) is a first-in-class, potent, highly selective FGFR4 inhibitor with IC50 of 1.1 nM. |
| PC-28678 |
CYY292
FGFR1 inhibitor
|
CYY292 is a potent and selective FGFR1 inhibitor with IC50 of 28, 28, and 78 nM for FGFR1, FGFR2, and FGFR3, does not inhibit FGFR4, alters FGFR1 phosphorylation both exogenously and endogenously through the negative feedback effect of Ser777. |
| PC-26972 |
KNT-0919
FGFR2/3 inhibitor
|
KNT-0919 is a potent, selective and covalent FGFR2/3 inhibitor, potently suppresses FGFR2- and FGFR3-driven Ba/F3 cells with IC50 of 1.1 nM and 0.20 nM respectively. |
| PC-26356 |
SOMCL-286
FGFR/VEGFR inhibitor
|
SOMCL-286 (Compound 25a) is a highly potent dual FGFR/VEGFR inhibitor with IC50 of 1.0 nM against FGFR1, shows nearly equally high potency against FGFR1, FGFR2 and VEGFR-2 with IC50 values of 1.0, 4.5 and 2.9 nM, respectively. |
| PC-26355 |
SOMCL-085
FGFR inhibitor
|
SOMCL-085 is a potent multi-targeted FGFR inhibitor with IC50 of 1.8, 1.9 and 6.9 nM for FGFR1-3, simultaneously inhibits VEGFR and PDGFR. |
| PC-26084 |
FGFR3 covalent inhibitor 10s
FGFR3 inhibitor
|
FGFR3 covalent inhibitor 10s is a selective, covalent FGFR3 inhibitor with IC50 of 6.8 nM, has 5-60-fold selectivity over FGFR1/2/4. |
| PC-25243 |
TCB-32
bFGF mimic, FGFR1 activator
|
TCB-32 is an agonistic small molecules that mimic binding of basic fibroblast growth factor (bFGF), shows a strong proliferative effect in NIH 3T3 cells, activates the same FGFR1-signaling pathway as bFGF. |
| PC-22625 |
FGF trap compound 57
FGF trap inhibitor
|
FGF trap compound 57 is a non-steroidal NSC12 derivative as FGF trap small molecule, shows anti-myeloma activity. |
