Chemical Structure : FGFR3 covalent inhibitor 10s
CAS No.:
FGFR3 covalent inhibitor 10s
Catalog No.: PC-26084Not For Human Use, Lab Use Only.
FGFR3 covalent inhibitor 10s is a selective, covalent FGFR3 inhibitor with IC50 of 6.8 nM, has 5-60-fold selectivity over FGFR1/2/4.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FGFR3 covalent inhibitor 10s is a selective, covalent FGFR3 inhibitor with IC50 of 6.8 nM, has 5-60-fold selectivity over FGFR1/2/4.
FGFR3 covalent inhibitor 10s is also effective against the common clinically acquired FGFR3V555M resistance mutation with an IC50 value of 19.2 nM.
FGFR3 covalent inhibitor 10s exhibited strong antiproliferative effects in FGFR3-driven RT112/84 cells (IC50 = 9.2 nM).
FGFR3 covalent inhibitor 10s (10-20 mg/kg) showed significant antitumor efficacy in the RT112/84 bladder cancer xenograft model.
Physicochemical Properties
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M.Wt
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486.58
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Formula
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C26H30N8O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(1-methyl-3-(2-((5-methyl-1-(2-morpholinoethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-1H-indol-6-yl)acrylamide
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References
1. Wenjian Zhu, et al. J Med Chem. 2026 Feb 6. doi: 10.1021/acs.jmedchem.5c02552.
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