Chemical Structure : SOMCL-085
CAS No.:
2126751-12-8
SOMCL-085
(SOMCL085)
Catalog No.: PC-26355Not For Human Use, Lab Use Only.
SOMCL-085 is a potent multi-targeted FGFR inhibitor with IC50 of 1.8, 1.9 and 6.9 nM for FGFR1-3, simultaneously inhibits VEGFR and PDGFR.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SOMCL-085 is a potent multi-targeted FGFR inhibitor with IC50 of 1.8, 1.9 and 6.9 nM for FGFR1-3, simultaneously inhibits VEGFR and PDGFR.
SOMCL-085 displays weaker activity against FGFR4 (IC50=319.9 nM).
SOMCL-085 significantly inhibits VEGFR1, VEGFR2, PDGFR-α, and PDGFR-β kinase activity, with potency that was equal or lower than that observed against FGFR1–3.
SOMCL-085 potently inhibits FGFR signaling, regardless of the mechanistic complexity of FGFR activation.
SOMCL-085 elicits significant effects against FGFR1–3-driven cancer cell proliferation via G1/S cell cycle arrest
SOMCL-085 (25 mg/kg and 50 mg/kg) significantly inhibits FGFR-mediated tumor growth in vivo, with tumor growth inhibition rates of 62.9% and 81.3% in FGFR2-amplified gastric cancer cell line SNU16 xenograft mouse models.
Physicochemical Properties
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M.Wt
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525.61
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Formula
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C30H31N5O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-((2-(4-(4-(2-hydroxyethyl)piperazin-1-yl)benzamido)pyridin-4-yl)oxy)-N-methyl-1-naphthamide
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References
1. Xi-Fei Jiang, et al. Acta Pharmacol Sin. 2018 Feb;39(2):243-250.
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