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Chemical Structure : NSC12
CAS No.: 102586-30-1
Catalog No.: PC-60628Not For Human Use, Lab Use Only.
NSC12 is an orally active small-molecule chemical that acts as an extracellular FGF trap, binds immobilized FGF3, FGF4, FGF6, FGF8, FGF16, FGF18, FGF20, and FGF22 with Kd of 16-120 uM, inhibits FGF-dependent tumor growth, angiogenesis and metastases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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NSC12 is an orally active small-molecule chemical that acts as an extracellular FGF trap, binds immobilized FGF3, FGF4, FGF6, FGF8, FGF16, FGF18, FGF20, and FGF22 with Kd of 16-120 uM, inhibits FGF-dependent tumor growth, angiogenesis and metastases.
NSC12 shows no apparent interaction for the other FGFs.
NSC12 inhibits HSPG/FGF/FGFR ternary complex formation induced by FGFR1(IIIc)-binding FGFs KATO III cells, inhibits FGFR1 phosphorylation in HUVECs stimulated by FGF2 with inhibition of HUVEC proliferation with IC50 of 6.5 uM.
NSC12 demonstrates significant inhibition of H520 tumor growth in vivo.
| M.Wt | 484.523 | |
| Formula | C24H34F6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(3β,20S)-24,24,24-Trifluoro-23-(trifluoromethyl)-21-norchol-5-ene-3,20,23-triol |
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1. Ronca R, et al. Cancer Cell. 2015 Aug 10;28(2):225-39.
2. Castelli R, et al. J Med Chem. 2016 May 26;59(10):4651-63.
3. Ronca R, et al. Oncotarget. 2017 Aug 1;8(47):82583-82592.
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