Catalog No.: PC-42352Not For Human Use, Lab Use Only.
PD-166866 is a potent, selective, ATP competitive FGFR1 inhibitor with IC50 of 52.4 nM, has no effect on c-Src, PDGFR-β, EGFR or InsR tyrosine kinases or on MEK, PKC and CDK4 (IC50>50 uM).
PD-166866 is a potent, selective, ATP competitive FGFR1 inhibitor with IC50 of 52.4 nM, has no effect on c-Src, PDGFR-β, EGFR or InsR tyrosine kinases or on MEK, PKC and CDK4 (IC50>50 uM).
PD-166866 inhibits FGFR-1 autophosphorylation in NIH 3T3 cells and L6 cells with IC50 of 10.8 and 3.1 nM, respectively.
PD-166866 inhibits bFGF-stimulated cell growth of L6 cells with IC50 of 24.1 nM, also is a a potent inhibitor of microvessel outgrowth (angiogenesis) from cultured artery fragments of human placenta.
