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Chemical Structure : PD-166866
CAS No.: 192705-79-6
Catalog No.: PC-42352Not For Human Use, Lab Use Only.
PD-166866 is a potent, selective, ATP competitive FGFR1 inhibitor with IC50 of 52.4 nM, has no effect on c-Src, PDGFR-β, EGFR or InsR tyrosine kinases or on MEK, PKC and CDK4 (IC50>50 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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PD-166866 is a potent, selective, ATP competitive FGFR1 inhibitor with IC50 of 52.4 nM, has no effect on c-Src, PDGFR-β, EGFR or InsR tyrosine kinases or on MEK, PKC and CDK4 (IC50>50 uM).
PD-166866 inhibits FGFR-1 autophosphorylation in NIH 3T3 cells and L6 cells with IC50 of 10.8 and 3.1 nM, respectively.
PD-166866 inhibits bFGF-stimulated cell growth of L6 cells with IC50 of 24.1 nM, also is a a potent inhibitor of microvessel outgrowth (angiogenesis) from cultured artery fragments of human placenta.
| M.Wt | 396.44296 | |
| Formula | C20H24N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10.33 mg/mL |
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| Chemical Name/SMILES |
Urea, N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)- |
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1. Panek RL, et al. J Pharmacol Exp Ther. 1998 Jul;286(1):569-77.
2. Sun JZ, et al. Am J Physiol Lung Cell Mol Physiol. 2001 Jul;281(1):L155-63.
3. Cassina P, et al. J Neurochem. 2005 Apr;93(1):38-46.
4. Calandrella N, et al. J Exp Clin Cancer Res. 2007 Sep;26(3):405-9.
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