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Chemical Structure : Infigratinib
CAS No.: 872511-34-7
Catalog No.: PC-43484Not For Human Use, Lab Use Only.
Infigratinib (NVP-BGJ398, BGJ398) is a potent, selective pan-FGFR inhibitor with IC50 of 0.9/1.0/1.4/60 nM for FGFR1/2/3/4, also shows high potenct against mutant FGFR3-K650E with IC50 of 4.9 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $88 | In stock | |
| 50 mg | $128 | In stock | |
| 100 mg | $218 | In stock | |
| 250 mg | $378 | In stock | |
| 1 g | Get quote |
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Infigratinib (NVP-BGJ398, BGJ398) is a potent, selective pan-FGFR inhibitor with IC50 of 0.9/1.0/1.4/60 nM for FGFR1/2/3/4, also shows high potenct against mutant FGFR3-K650E with IC50 of 4.9 nM.
Infigratinib (NVP-BGJ398, BGJ398) inhibits the proliferation of the FGFR1-, FGFR2-, and FGFR3-dependent BaF3 cells with IC50 of low nanomolar range.
Infigratinib (NVP-BGJ398, BGJ398) shows significant antitumor activity in RT112 bladder cancer xenografts models overexpressing wild-type FGFR3.
Infigratinib (NVP-BGJ398, BGJ398) significantly inhibits the growth of FGFR2-mutated endometrial cancer xenograft models, also ameliorates FGF23-mediated hypophosphatemic rickets in mouse models.
| M.Wt | 560.48 | |
| Formula | C26H31Cl2N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 27 mg/mL |
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| Chemical Name/SMILES |
Urea, N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl- |
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1. Guagnano V, et al. J Med Chem. 2011 Oct 27;54(20):7066-83.
2. Guagnano V, et al. Cancer Discov. 2012 Dec;2(12):1118-33.
3. Konecny GE, et al. Mol Cancer Ther. 2013 May;12(5):632-42.
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