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Chemical Structure : E7090
Catalog No.: PC-35144Not For Human Use, Lab Use Only.
E7090 (Tasurgratinib) is a potent, selective, orally available inhibitor of FGFR1, -2, and -3 with IC50 of 0.71, 0.50 and 1.2 nM, weakly inhibits FGFR4 (IC50=120 nM).
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E7090 (Tasurgratinib) is a potent, selective, orally available inhibitor of FGFR1, -2, and -3 with IC50 of 0.71, 0.50 and 1.2 nM, weakly inhibits FGFR4 (IC50=120 nM).
E7090 inhibits only 3 tyrosine kinases (RET, DDR2, and FLT1) with IC50 lower than 10 nM among the 93 kinases, also potently inhibits mutant FGFR3 (K650E and K650M, IC50=3.1 and 16 nM).
E7090 inhibits FGFR phosphorylation and cell proliferation of SNU-16 cells with IC50 of 1.2 and 5.7 nM, respectively.
E7090 shows selective antiproliferative activity against cancer cell lines harboring FGFR abnormalities.
E7090 exhibits antitumor activity and inhibits FGFR signaling in a mouse xenograft model of SNU-16 human gastric cancer.
| M.Wt | 587.677 | |
| Formula | C32H37N5O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Watanabe Miyano S, et al. Mol Cancer Ther. 2016 Nov;15(11):2630-2639.
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