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Chemical Structure : Dovitinib lactate
CAS No.: 692737-80-7
Catalog No.: PC-42452Not For Human Use, Lab Use Only.
Dovitinib lactate (CHIR-258, TKI-258) is a multitargeted RTK inhibitor of class III, IV, and V RTKs with IC50 of 1/2/36/8/9 nM for FLT3/c-KIT/c-Fms/FGFR1/FGFR3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | $388 | In stock | |
| 250 mg | Get quote |
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Dovitinib lactate (CHIR-258, TKI-258) is a multitargeted RTK inhibitor of class III, IV, and V RTKs with IC50 of 1/2/36/8/9 nM for FLT3/c-KIT/c-Fms/FGFR1/FGFR3, respectively.
Dovitinib also inhibits VEGFR1/2/3 (IC50=10/13/8 nM) and PDGFRβ/α (IC50=27/210 nM).
Dovitinib selectively inhibits the growth of B9 cells and human myeloma cell lines expressing wild-type (WT) or activated mutant FGFR3.
Dovitinib inhibits downstream ERK 1/2 phosphorylation and induces cytostatic and cytotoxic effects.
Dovitinib demonstrates activity in a xenograft mouse model of FGFR3 MM; orally active.
| M.Wt | 482.5073832 | |
| Formula | C24H27FN6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Propanoic acid, 2-hydroxy-, compd. with 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone (1:1) |
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1. Trudel S, et al. Blood. 2005 Apr 1;105(7):2941-8.
2. Lopes de Menezes DE, et al. Clin Cancer Res. 2005 Jul 15;11(14):5281-91.
3. Xin X, et al. Clin Cancer Res. 2006 Aug 15;12(16):4908-15.
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