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Chemical Structure : CPL304110
Catalog No.: PC-72218Not For Human Use, Lab Use Only.
CPL304110 (CPL-304110) is a selective and potent pan-FGFR inhibitor with IC50 of 0.75 nM, 0.50 nM, 3.05 nM against FGFR1, 2, 3, shows weaken acitvity against FGFR4 with IC50 of 87.9 nM.
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CPL304110 (CPL-304110) is a selective and potent pan-FGFR inhibitor with IC50 of 0.75 nM, 0.50 nM, 3.05 nM against FGFR1, 2, 3, shows weaken acitvity against FGFR4 with IC50 of 87.9 nM.
CPL304110 shows potent anti-tumor activity in vivo, CPL304110 is currently under evaluation in phase I clinical trial for the treatment of bladder, gastric and squamous cell lung cancers.
| M.Wt | 445.567 | |
| Formula | C26H31N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yamani A, et al. Eur J Med Chem. 2021 Jan 15;210:112990.
2. Kitowska K, et al. Front Oncol. 2021 Apr 7;11:633410.
3. Zarczynska I, et al. Cells. 2021 Nov 30;10(12):3363.
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