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FGFR2 inhibitor 38

Chemical Structure : FGFR2 inhibitor 38

CAS No.: 2677709-81-6

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FGFR2 inhibitor 38

Catalog No.: PC-72306Not For Human Use, Lab Use Only.

FGFR2 inhibitor 38 is a potent, selective FGFR2 inhibitor with IC50 of 29 nM, exhibits moderate selectivity for FGFR2 over FGFR1/3 (>13.4 fold).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    FGFR2 inhibitor 38 is a potent, selective FGFR2 inhibitor with IC50 of 29 nM, exhibits moderate selectivity for FGFR2 over FGFR1/3 (>13.4 fold).
    FGFR2 inhibitor 38 exhibited modest potency against SUM52 cell with an IC50 value of 700 nM.

    Physicochemical Properties

    M.Wt 370.456
    Formula C23H22N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(3-(4-(piperazin-1-yl)phenyl)-1H-indazol-6-yl)phenol

    References

    1. Lewis D Turner, et al. J Med Chem. 2022 Jan 27;65(2):1481-1504.

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