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Chemical Structure : DW14383
Catalog No.: PC-21612Not For Human Use, Lab Use Only.
DW14383 is a potent, selective and irreversible inhibitor of FGFR1-4 with IC50 of <0.3 nM, 1.1 nM, <0.3 nM and 0.5 nM for FGFR1/2/3/4 respectively.
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DW14383 is a potent, selective and irreversible inhibitor of FGFR1-4 with IC50 of <0.3 nM, 1.1 nM, <0.3 nM and 0.5 nM for FGFR1/2/3/4 respectively.
DW14383 displays >1100-fold selectivity for FGFR1 over recombinant KDR.
DW14383 is more potent than TAS-120 and comparable to AZD4547.
DW14383 (20 nM) completely inhibited FGFR4 phosphorylation and ERK phosphorylation in the Hep3B cells.
DW14383 inhibited the proliferation of FGFR-addicted cells by arresting cells at G1/S phase rather than apoptosis, selectively inhibited the BaF3/TEL-FGFR1 cell proliferation (IC50 < 0.2 nM).
DW14383 (25 mg/kg) effectively inhibited tumor growth in NCI-H1581 and Hep3B subcutaneous xenograft models, significantly suppressed FGFR signaling and inhibited tumor cell proliferation and angiogenesis in FGFR-dependent transplanted tumor tissues.
| M.Wt | 498.40 | |
| Formula | C22H20BrN5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Meng-di Dai, et al. Acta Pharmacol Sin. 2021 Sep;42(9):1498-1506.
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