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Chemical Structure : LHQ490
Catalog No.: PC-22316Not For Human Use, Lab Use Only.
LHQ490 is a potent, highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor with Ic50 of 5.2 nM, >61-, >34-, and >293-fold selective against FGFR1, FGFR3, and FGFR4.
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LHQ490 is a potent, highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor with Ic50 of 5.2 nM, >61-, >34-, and >293-fold selective against FGFR1, FGFR3, and FGFR4.
LHQ490 also exhibits high selectivity in a panel of 416 kinases.
LHQ490 efficiently suppresses the proliferation of BaF3-FGFR2 cells with IC50 of 1.4 nM, and displays >70- and >714-fold selectivity against BaF3-FGFR1 and the parental BaF3 cells, respectively.
LHQ490 potently suppresses the FGFR2 signaling pathways, selectively inhibits FGFR2-driven cancer cell proliferation, and induces apoptosis of FGFR2-driven cancer cells.
| M.Wt | 528.63 | |
| Formula | C30H33FN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huiqiong Li, et al. Eur J Med Chem. 2024 May 4:272:116473.
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