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Chemical Structure : FGFR2/3 inhibitor 29
Catalog No.: PC-49450Not For Human Use, Lab Use Only.
FGFR2/3 inhibitor 29 is a potent and selective inhibitor of FGFR2/3 wild-type and gatekeeper mutant with IC50 of 1 nM and 0.5 nM for FGFR2 and FGFR3, respectively.
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FGFR2/3 inhibitor 29 is a potent and selective inhibitor of FGFR2/3 wild-type and gatekeeper mutant with IC50 of 1 nM and 0.5 nM for FGFR2 and FGFR3, respectively.
FGFR2/3 inhibitor 29 displays >40-fold selectivity over FGFR1 and FGFR4.
FGFR2/3 inhibitor 29 potently inhibits FGFR3 V555L and V555M gatekeeper mutants with IC50 of 2.7 nM and 6.1 nM, respectively.
| M.Wt | 450.517 | |
| Formula | C23H22D3N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shvartsbart A, et al. J Med Chem. 2022 Nov 10. doi: 10.1021/acs.jmedchem.2c01366.
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