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FGFR2/3 inhibitor 29

Chemical Structure : FGFR2/3 inhibitor 29

CAS No.: 2640352-86-7

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FGFR2/3 inhibitor 29

Catalog No.: PC-49450Not For Human Use, Lab Use Only.

FGFR2/3 inhibitor 29 is a potent and selective inhibitor of FGFR2/3 wild-type and gatekeeper mutant with IC50 of 1 nM and 0.5 nM for FGFR2 and FGFR3, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    FGFR2/3 inhibitor 29 is a potent and selective inhibitor of FGFR2/3 wild-type and gatekeeper mutant with IC50 of  1 nM and 0.5 nM for FGFR2 and FGFR3, respectively.
    FGFR2/3 inhibitor 29 displays >40-fold selectivity over FGFR1 and FGFR4.
    FGFR2/3 inhibitor 29 potently inhibits FGFR3 V555L and V555M gatekeeper mutants with IC50 of 2.7 nM and 6.1 nM, respectively.

    Physicochemical Properties

    M.Wt 450.517
    Formula C23H22D3N7O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-5-(6-(1-isopropyl-1H-pyrazol-4-yl)-5-((tetrahydrofuran-3-yl)oxy)pyrazolo[1,5-a]pyrimidin-3-yl)-N-(methyl-d3)nicotinamide

    References

    1. Shvartsbart A, et al. J Med Chem. 2022 Nov 10. doi: 10.1021/acs.jmedchem.2c01366.

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