Chemical Structure : Gunagratinib
CAS No.:
2211082-53-8
Gunagratinib
(ICP-192, ICP192, ICP-CL-00301)
Catalog No.: PC-38396Not For Human Use, Lab Use Only.
ICP-192 (Gunagratinib) is a novel potent, covalent pan-FGFR (fibroblast growth factor receptors) inhibitor, potently and selectively inhibits FGFR activities irreversibly by covalent binding.
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
ICP-192 (Gunagratinib) is a novel potent, covalent pan-FGFR (fibroblast growth factor receptors) inhibitor, potently and selectively inhibits FGFR activities irreversibly by covalent binding.
ICP-192 (Gunagratinib) overcomes the acquired resistance to the first-generation reversible FGFR inhibitors, e.g., infigratinib.
Physicochemical Properties
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M.Wt
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423.473
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Formula
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C22H25N5O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-1-(1-acryloylpyrrolidin-3-yl)-3-((3,5-dimethoxyphenyl)ethynyl)-5-(methylamino)-1H-pyrazole-4-carboxamide
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References
1. Ye Guo, et al. 2021 ASCO Annual Meeting I.
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