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Chemical Structure : ASP6918
Catalog No.: PC-21640Not For Human Use, Lab Use Only.
ASP6918 (ASP 6918) is a highly potent, covalent KRAS G12C inhibitor with IC50 of 28 nM in cell-free assays, and pERK inhibition IC50 of 3.7 nM in NCI-H1373 cells.
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ASP6918 (ASP 6918) is a highly potent, covalent KRAS G12C inhibitor with IC50 of 28 nM in cell-free assays, and pERK inhibition IC50 of 3.7 nM in NCI-H1373 cells.
ASP6918 potently inhibits cell growth of NCI-H1373 cell line with IC50 of 6.1 nM.
ASP6918 induces significant suppression of ERK phosphorylation at doses of 40 and 60 mg/kg in an NCI-H1373 xenograft mouse model.
ASP6918 (10-60 mg/ kg, p.o.) exhibits antitumor growth inhibition and regression in an NCI-H1373 xenograft mouse model.
| M.Wt | 621.79 | |
| Formula | C36H43N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tomoyoshi Imaizumi, et al. Bioorg Med Chem. 2023 Dec 27:98:117581.
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