Chemical Structure : ASP6918
CAS No.:
2242418-18-2
ASP6918
(ASP 6918, ASP-6918)
Catalog No.: PC-21640Not For Human Use, Lab Use Only.
ASP6918 (ASP 6918) is a highly potent, covalent KRAS G12C inhibitor with IC50 of 28 nM in cell-free assays, and pERK inhibition IC50 of 3.7 nM in NCI-H1373 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ASP6918 (ASP 6918) is a highly potent, covalent KRAS G12C inhibitor with IC50 of 28 nM in cell-free assays, and pERK inhibition IC50 of 3.7 nM in NCI-H1373 cells.
ASP6918 potently inhibits cell growth of NCI-H1373 cell line with IC50 of 6.1 nM.
ASP6918 induces significant suppression of ERK phosphorylation at doses of 40 and 60 mg/kg in an NCI-H1373 xenograft mouse model.
ASP6918 (10-60 mg/ kg, p.o.) exhibits antitumor growth inhibition and regression in an NCI-H1373 xenograft mouse model.
Physicochemical Properties
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M.Wt
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621.79
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Formula
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C36H43N7O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(+)-1-(7-{8-ethoxy-7-(5-methyl-1H-indazol-4-yl)-2-[(1-methylpiperidin-4-yl)oxy]-6-vinylquinazolin-4-yl}-2,7-diazaspiro[3.5]non-2-yl)prop-2-en-1-one
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References
1. Tomoyoshi Imaizumi, et al. Bioorg Med Chem. 2023 Dec 27:98:117581.
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