ASP7663 is a potent, selective, orally active TRPA1 receptor agonist with EC50 of 0.51, 0.54 and 0.50 uM for human, rat and mouse TRPA1, respectively.
ASP7663 concentration-dependently stimulates 5-HT release from QGP-1 cells with EC50 of 72.5 uM.
ASP7663 significantly improves the loperamide-induced delay in colonic transit in mice, also significantly inhibits colorectal distension (CRD)-induced abdominal pain response in rats.
