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Chemical Structure : ASP7663
CAS No.: 1190217-35-6
Catalog No.: PC-61156Not For Human Use, Lab Use Only.
ASP7663 is a potent, selective, orally active TRPA1 receptor agonist with EC50 of 0.51, 0.54 and 0.50 uM for human, rat and mouse TRPA1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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ASP7663 is a potent, selective, orally active TRPA1 receptor agonist with EC50 of 0.51, 0.54 and 0.50 uM for human, rat and mouse TRPA1, respectively.
ASP7663 concentration-dependently stimulates 5-HT release from QGP-1 cells with EC50 of 72.5 uM.
ASP7663 significantly improves the loperamide-induced delay in colonic transit in mice, also significantly inhibits colorectal distension (CRD)-induced abdominal pain response in rats.
| M.Wt | 263.268 | |
| Formula | C14H14FNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-[7-fluoro-1-(2-methylpropyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]aceticacid |
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1. Kojima R, et al. Eur J Pharmacol. 2014 Jan 15;723:288-93.
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