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ASP7967

Chemical Structure : ASP7967

CAS No.: 1246834-49-0

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ASP7967 (ASP-7967, ASP 7967)

Catalog No.: PC-20404Not For Human Use, Lab Use Only.

ASP7967 (ASP-7967) is a cell-permeable and low-toxic compound of RNA aptamer AC17-4 with SPR binding Kd of 12 nM, activates gene expression (>10-fold) in aptazyme-based riboswitches with EC50 of 2.3 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ASP7967 (ASP-7967) is a cell-permeable and low-toxic compound of RNA aptamer AC17-4 with SPR binding Kd of 12 nM, activates gene expression (>10-fold) in aptazyme-based riboswitches with EC50 of 2.3 uM.
    Oral administration of 100 mg/kg ASP7967 upregulated the serum hEPO concentration by ∼7.2-fold over the vehicle control in mice.

    Physicochemical Properties

    M.Wt 406.40
    Formula C20H16F2N8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N2,N4-bis(4-fluorophenyl)-N6-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine

    References

    1. Keisuke Fukunaga, et al. J Am Chem Soc. 2023 Mar 29. doi: 10.1021/jacs.2c12332.

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