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AT-7519 trifluoroacetate

Chemical Structure : AT-7519 trifluoroacetate

CAS No.: 1431697-85-6

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AT-7519 trifluoroacetate (AT 7519 trifluoroacetate;AT7519 trifluoroacetate)

Catalog No.: PC-45912Not For Human Use, Lab Use Only.

AT-7519 trifluoroacetate (AT7519) is a potent, selective CDK2 inhibitor with IC50 of 47 nM, also inhibits CDK1/4/5 with IC50 of 190/67/18 nM and shows selectivity over some kinases (Aurora A, IR kinase, MEK, PDK1, c-Abl, IC50>10 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AT-7519 trifluoroacetate (AT7519)  is a potent, selective CDK2 inhibitor with IC50 of 47 nM, also inhibits CDK1/4/5 with IC50 of 190/67/18 nM and shows selectivity over some kinases (Aurora A, IR kinase, MEK, PDK1, c-Abl, IC50>10 uM).
AT-7519 has antiproliferative activity against HCT116 cells with IC50 of 82 nM.
AT-7519 exhibits good profile against cytochrome P450 isoforms (<30% inhibition at 10 uM for 1A2, 2D6, 3A4, 2C9, 2C19). 

Physicochemical Properties

M.Wt 496.2678
Formula C18H18Cl2F3N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Pyrazole-3-carboxamide, 4-[(2,6-dichlorobenzoyl)amino]-N-4-piperidinyl-, 2,2,2-trifluoroacetate (1:1)

References

1. Wyatt PG, et al. J Med Chem. 2008 Aug 28;51(16):4986-99.

2. Squires MS, et al. Mol Cancer Ther. 2009 Feb;8(2):324-32.

3. Dolman ME, et al. Clin Cancer Res. 2015 Nov 15;21(22):5100-9.

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