Chemical Structure : ATF4/CHOP inhibitor T-22
CAS No.:
3104243-75-3
ATF4/CHOP inhibitor T-22
Catalog No.: PC-28697Not For Human Use, Lab Use Only.
ATF4/CHOP inhibitor T-22 is a potent, specific CHOP/ATF4 inhibitor, inhibits CHOP expresion with IC50 of 1.41 uM in CHOP-Luc assay under ER stress conditions, significantly inhibits ATF4 mRNA expression.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ATF4/CHOP inhibitor T-22 is a potent, specific CHOP/ATF4 inhibitor, inhibits CHOP expresion with IC50 of 1.41 uM in CHOP-Luc assay under ER stress conditions, significantly inhibits ATF4 mRNA expression.
T-22 (10 uM) inhibited ER stress-induced CHOP mRNA expression, significantly inhibits both CHOP and ATF4.
T-22 does not affect the immediate upstream regulators of CHOP/ATF4, phosphorylation of PERK or eIF2α, and does not modulate ER stress in general as it does not affect the levels of IRE1α, XBP-1 splicing (XBP-1s), or ATF6.
T-22 inhibits neuronal ER stress and provide significant neuroprotection of RGC somata and axons in the traumatic ON crush (ONC) model.
CH-126 promotes significant survival of RGCs somata and axons and preserve visual function in the mouse silicone oil-induced ocular hypertension glaucoma model.
Physicochemical Properties
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M.Wt
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409.40
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Formula
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C17H10F3N3O2S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl 2-((6-(trifluoromethyl)benzo[d]thiazol-2-yl)amino)benzo[d]thiazole-6-carboxylate
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References
1. Li M, et al. Cell Rep. 2026 Oct 27;45(11):118225.
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