ATI-2341 TFA is a potent, selective and allosteric CXCR4 agonist with EC50 of 194 nM. ATI-2341 induces CXCR4-dependent calcium flux in U87 glioblastoma cells (IC50=140 nM), receptor internalization, and chemotaxis in cell-based assays. ATI-2341 also displays potent efficacy in the mobilization of PMNs and HSPCs in mice and nonhuman primates.
Physicochemical Properties
M.Wt
2256.82 (free base)
Formula
C104H178N26O25S2.xC2HF3O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
L-Leucine, N-(1-oxohexadecyl)-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-tyrosyl-L-arginyl- TFA salt
References
1. Tchernychev B, et al. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22255-9.
2. Janz JM, et al. J Am Chem Soc. 2011 Oct 12;133(40):15878-81.
3. Quoyer J, et al. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5088-97.
4. Luo J, et al. Mol Pharmacol. 2017 Jun;91(6):554-566.
