Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ATN-224
CAS No.: 649749-10-0
Catalog No.: PC-61677Not For Human Use, Lab Use Only.
ATN-224 (Choline tetrathiomolybdate, WTX-101) is a specific, high-affinity copper binder that inhibits CuZn superoxide dismutase 1 (SOD1) with IC50 of 0.33 uM against purified bovine SOD1, leading to antiangiogenic and antitumour effects.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ATN-224 (Choline tetrathiomolybdate, WTX-101) is a specific, high-affinity copper binder that inhibits CuZn superoxide dismutase 1 (SOD1) with IC50 of 0.33 uM against purified bovine SOD1, leading to antiangiogenic and antitumour effects.
ATN-224 shows no binding to calcium, iron, magnesium, zinc, or manganese ions at 1 mM.
ATN-224 inhibits HUVEC proliferation with IC50 1.4 uM.
ATN-224 shows a potential therapy against Wilson's disease.
| M.Wt | 432.542 | |
| Formula | C10H28MoN2O2S4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-hydroxy-N,N,N-trimethyl-ethanaminium, tetrathioxomolybdate |
|
1. Juarez JC, et al. Clin Cancer Res. 2006 Aug 15;12(16):4974-82.
2. Doñate F, et al. Br J Cancer. 2008 Feb 26;98(4):776-83.
3. Calderon-Aparicio A, et al. Oncotarget. 2015 Oct 6;6(30):29771-81.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
