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AUDA-BE

Chemical Structure : AUDA-BE

CAS No.: 776300-37-9

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AUDA-BE (sEH inhibitor)

Catalog No.: PC-70251Not For Human Use, Lab Use Only.

AUDA-BE is the prodrug of AUDA, a potent inhibitor of sEH (soluble epoxide hydrolase) with IC50 of 50 nM and 100 nM for mouse sEH and human sEH, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AUDA-BE is the prodrug of AUDA, a potent inhibitor of sEH (soluble epoxide hydrolase) with IC50 of 50 nM and 100 nM for mouse sEH and human sEH, respectively.
    AUDA-BE prevents LPS-induced mortality and preserved systolic blood pressure, reduces NO production in mice.

    Physicochemical Properties

    M.Wt 448.692
    Formula C27H48N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    butyl 12-(3-(adamantan-1-yl)ureido)dodecanoate

    References

    1. Morisseau C, et al. Biochem Pharmacol. 2002 May 1;63(9):1599-608.

    2. Schmelzer KR, et al. Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9772-7.

    3. Motoki A, et al. Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2128-34.

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