AVI-6451 | SARS-CoV-2 Mac1 inhibitor | Probechem Biochemicals

Chemical Structure : AVI-6451

Catalog No.: PC-26183Not For Human Use, Lab Use Only.

AVI-6451 is a potent and selective inhibitor of SARS-CoV-2 ADP-ribosylhydrolase Mac1 with IC50 of 28 nM, ITC Kd of 55 nM.

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Biological Activity

AVI-6451 is a potent and selective inhibitor of SARS-CoV-2 ADP-ribosylhydrolase Mac1 with IC50 of 28 nM, ITC Kd of 55 nM.

M.Wt	355.37
Formula	C18H18FN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((8-cyclopropyl-6-fluoro-9H-pyrimido[4,5-b]indol-4-yl)amino)-4,4-dimethyloxazolidin-2-one

1. Jaishankar P, et al. J Med Chem. 2026 Jan 8;69(1):553-573.