Chemical Structure : AVX420
CAS No.:
1621517-60-9
AVX420
(AVX-420, GK420)
Catalog No.: PC-23791Not For Human Use, Lab Use Only.
AVX420 (GK420) is a potent and selective inhibitor of Group IVA cytosolic phospholipase A2 (cPLA2α), inhibits arachidonic acid (AA) release in IL-1β-stimulated SW982 synoviocyte with IC50 of 0.09 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AVX420 (GK420) is a potent and selective inhibitor of Group IVA cytosolic phospholipase A2 (cPLA2α), inhibits arachidonic acid (AA) release in IL-1β-stimulated SW982 synoviocyte with IC50 of 0.09 uM.
AVX420 could act as a prodrug generating the corresponding acid, which can bind to the active site of cPLA2α via multiple interactions.
AVX420 dose-dependently inhibited LTB4, PGE2 and TXB2 with IC50 values of 317 nM, 1.1 μM, and 2.2 μM respectively, in calcium ionophore A23187 stimulated PBMCs.
AVX420 prevents the stimulated release of AA and production of both COX and LOX-derived metabolites of AA in primary human cells with no discernable inhibition of COX or LOX enzymes.
AVX420 causes oxidative stress-dependent cell death in acute leukemia cells.
AVX420 dose-dependently reduces the viability of multiple myeloma cells and induces apoptosis in vitro.
Physicochemical Properties
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M.Wt
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391.48
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Formula
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C20H25NO5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl 2-(2-(4-(heptyloxy)phenoxy)acetyl)thiazole-4-carboxylate
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References
1. Ashcroft FJ, et al. Nat Commun. 2025 Jan 2;16(1):164.
2. Mahammad N, et al. Molecules. 2021 Dec 9;26(24):7447.
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