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AW-006

Chemical Structure : AW-006

CAS No.: 2209961-90-8

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AW-006 (AW006)

Catalog No.: PC-27863Not For Human Use, Lab Use Only.

AW-006 is a small-molecule modulator targeting Sorting nexin 10 (SNX10), selectively inhibiting osteoclast resorptive function while maintaining normal osteoclastogenesis in vitro.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AW-006 is a small-molecule modulator targeting Sorting nexin 10 (SNX10), selectively inhibiting osteoclast resorptive function while maintaining normal osteoclastogenesis in vitro.
AW-006 interacts with SNX10 and reduces its thermal stability.
AW-006 abnormally enhances the SNX10 interacting within vesicular trafficking regulator Rab7 in living cells.
AW-006 shows anti-resorptive efficacy in ovariectomized mice, shows therapeutic potential in estrogen deficiency-induced bone loss.

Physicochemical Properties

M.Wt 282.81
Formula C15H23ClN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(5-chloro-2-(dimethylamino)phenyl)-5-methylhexanamide

References

1. Li Y, et al. J Bone Miner Res. 2026 Aug 23:zjag126.

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