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Chemical Structure : AWZ1066S
CAS No.: 2239272-16-1
Catalog No.: PC-21811Not For Human Use, Lab Use Only.
AWZ1066S is a potent, highly specific anti-Wolbachia inhibitor with EC50 of 2.5 nM against Wolbachia in cell-based assays, and IC50 of 121 nM in microfilaria assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AWZ1066S is a potent, highly specific anti-Wolbachia inhibitor with EC50 of 2.5 nM against Wolbachia in cell-based assays, and IC50 of 121 nM in microfilaria assays.
AWZ1066 reduces Wolbachia within the microfilariae (mf) of the human parasite B. malayiwith an EC50 of 150 nM.
AWZ1066S (100 mg/kg) reduces Wolbachia by 98% after only 7 d orally administered treatment in adult B. malayi SCID mouse model.
AWZ1066S shows minimal impact on the gut microbiota, lowering the risk of dysbiosis and the selection and emergence of resistance.
| M.Wt | 404.40 | |
| Formula | C19H19F3N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[(3S)-3-Methyl-4-morpholinyl]-N-[[2-(trifluoromethyl)-3-pyridinyl]methyl]pyrido[2,3-d]pyrimidin-4-amine |
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1. Hong W. D. et al. Proc. Natl. Acad. Sci. U. S. A. 116, 1414–1419.
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