Cat. No. |
Product Name |
Information |
PC-21022 |
OSM-S-106
PfAsnRS inhibitor
|
OSM-S-106 is a reaction hijacking inhibitor of Plasmodium falciparum asparagine tRNA synthetase (PfAsnRS), inhibits the 3D7 line of P. falciparum with IC50 of 58 nM. |
PC-49827 |
UCB7362
Pf PMX inhibitor
|
UCB7362 (UCB 7362) is a potent, selective inhibitor of malaria parasite plasmepsin X (PMX) with IC50 of 7 nM for P. falciparum (Pf PMX) and plasmodium vivax (Pv PMX), SPR Kd of 5.5 nM, also inhibits PMIX with IC50 of 142 nM. |
PC-49608 |
Halofuginol
PfcPRS inhibitor
|
Halofuginol (MAZ1805) is a halofuginone analog targeting the Plasmodium falciparum prolyl-tRNA synthetase (PfcPRS, Ki=71.1 nM), is highly active against both liver and asexual blood stages of the malaria parasite (EC50=5.8 nM, P. falciparum 3D7 parasite strain). |
PC-49604 |
TBAJ-587
Anti-tuberculosis
|
TBAJ-587 is a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90 of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively. |
PC-49324 |
KNX-002
TgMyoA inhibitor
|
KNX-002 (KNX002) is a potent, specific inhibitor of Toxoplasma gondii class XIV myosin TgMyoA, inhibits TgMyoA ATPase activity with IC50 of 2.8 uM, shows little to no effect on any of the vertebrate myosins. |
PC-49005 |
MBX-4055
P. falciparum PSAC inhibitor
|
MBX-4055 is a potent and specific antimalarial compound with IC50 of 42 nM (P. falciparum growth inhibition), acts directly on plasmodial surface anion channel (PSAC, Target K0.5=21 nM) to quantitatively abolish parasite-induced permeability changes. |
PC-49003 |
MBX-2366
P. falciparum PSAC inhibitor
|
MBX-2366 (ISG-21) is a potent and specific antimalarial compound with IC50 of 3 nM (P. falciparum growth inhibition), acts directly on plasmodial surface anion channel (PSAC, Target K0.5=2 nM) to quantitatively abolish parasite-induced permeability changes. |
PC-47069 |
NPD-008
TbrPDEB1 inhibitor
|
NPD-008 is a potent, selective Trypanosoma brucei PDE B1 (TbrPDEB1) inhibitor with Ki of 100 nM, exhibits antitrypanosomal effects with IC50 of 5.5 uM. |
PC-73056 |
TCMDC-135051
PfCLK3 inhibitor
|
TCMDC-135051 is a potent PfCLK3 inhibitor with IC50 of 40 nM. |
PC-72991 |
AN7973
Parasite inhibitor
|
AN7973 (AN-7973) is a novel drug candidate for treatment of cryptosporidiosis, potently inhibits multiple C. parvum isolates and the C. hominis TU502 isolate in vitro. |
PC-72957 |
Pyronaridine
Pf β-hematin inhibitor
|
Pyronaridine is a fast-acting (chloroquine-like) drug that has the demonstrated ability to inhibit P. falciparum β-hematin formation in vitro, suppress the selection of M5717-resistant mutants. |
PC-72956 |
M5717
PfeEF2 inhibitor
|
M5717 (DDD107498, M 5717, Cabamiquine) is a potent, specific P. falciparum translation elongation factor 2 inhibitor (PfeEF2). |