| Cat. No. |
Product Name |
Information |
| PC-49849 |
DSM161
AbDHODH inhibitor
|
DSM161 (DSM 161) is a high potent A. baumannii DHODH (AbDHODH) inhibitor, has MIC <1 ug/mL against geographically diverse A. baumannii strains, including meropenem-resistant isolates. |
| PC-49833 |
WEHI-600
Pf PMX inhibitor
|
WEHI-600 is a potent, small molecule inhibitor of the aspartic proteases Plasmepsin X (PMX) with IC50 of 3 nM, possess potent anti-parasitic activity (P. falciparum parasite, IC50=7 nM). |
| PC-49832 |
WEHI-601
Pf PMX inhibitor
|
WEHI-601 is a potent, small molecule inhibitor of the aspartic proteases Plasmepsin X (PMX) with IC50 of 5 nM, possess potent anti-parasitic activity (P. falciparum parasite, IC50=9 nM). |
| PC-49831 |
CWHM-117
Pf PM-II inhibitor
|
CWHM-117 is potent nanomolar inhibitor of the Plasmodium aspartic proteases PM-II and PM-IV with IC50 of 4 and 15 nM respectively, exhibits IC50 of 463 nM in the Pf 3D7 infected RBC assays. |
| PC-49830 |
TCMDC-136879
|
TCMDC-136879 is a cyclic acyl guanidine compound with antimalarial activity. |
| PC-49829 |
WM382
Pf PMX inhibitor
|
WM382 (WM-382) is a potent, specific dual inhibitor of the aspartic proteases Plasmepsin IX and X (PMIX and PMX) with IC50 of 0.06 nM (PMX), blocks multiple stages of the Plasmodium life cycle. |
| PC-49610 |
Halofuginone
PfcPRS inhibitor
|
Halofuginone (RU-19110) is a small molecule febrifugine analog targeting the Plasmodium falciparum prolyl-tRNA synthetase (PfcPRS, Ki=18.3 nM), inhibits wildtype Dd2 strain of P. falciparum with EC50 of 0.5 nM. |
| PC-49609 |
Febrifugine
PfcPRS inhibitor
|
Febrifugine is a quinazolinone alkaloid for treating malaria-induced fever for about 2000 years, targets the Plasmodium falciparum prolyl-tRNA synthetase (PfcPRS). |
| PC-49605 |
SCR0911
Cyt bc inhibitor
|
SCR0911 is a potent malarial cytochrome bc1 inhibitor, inhibits cell growth and ATP synthesis in both the fast- and slow-growing M. smegmatis and M. bovis bacillus Calmette-Guérin, respectively. |
| PC-49603 |
AWE402
Cyt bcc-aa3 inhibitor
|
AWE402 (AWE-402) is a small molecule inhibitor targeting M. tuberculosis cytochrome bcc-aa3 of the electron transport chain (ETC), shows MIC value of 5 nM activity against Mycobacterium tuberculosis H37Rv. |
| PC-49602 |
CK-2-63
Cyt bd inhibitor
|
CK-2-63 is a potent first-in-class M. tuberculosis cytochrome bd (cyt bd) inhibitor, demonstrates growth suppression of M. tuberculosis H37Rv with IC50 of 3.7 uM. |
| PC-49323 |
KNX-115
PfMyoA inhibitor
|
KNX-115 (KNX115) is a potent, selective inhibitor of plasmodium falciparum myosin A (PfMyoA), inhibits PfMyoA actin-activated ATPase with Ki of 17 nM, >50-fold selectivity against cardiac, skeletal, and smooth muscle myosins. |
