Chemical Structure : Antimalarial compound 49c
CAS No.:
1422207-75-7
Antimalarial compound 49c
Catalog No.: PC-35257Not For Human Use, Lab Use Only.
Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM.
Antimalarial compound 49c blocks invasion and egress of P. falciparum without impacting intraerythrocytic growth, specifically inhibits recombinant PfPMIX and PfPMX (r-PMIXFlag and r-PMXFlag), recapitulating the defect in invasion and egress of P. falciparum in the erythrocytic blood stages.
Antimalarial compound 49c also interferes with invasion and egress in T. gondii by targeting TgASP3
Physicochemical Properties
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M.Wt
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514.67
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Formula
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C31H38N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((2S,3R)-3-hydroxy-1-phenyl-4-(((R)-1-phenylethyl)amino)butan-2-yl)-4-(4-methylpiperazine-1-carbonyl)benzamide
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References
1. Ciana C, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):658-62.
2. Mukherjee B, et al. EMBO J. 2018 Apr 3;37(7). pii: e98047.
3. Pino P, et al. Science. 2017 Oct 27;358(6362):522-528.
4. Dogga SK, et al. Elife. 2017 Sep 12;6. pii: e27480.
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