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Chemical Structure : INE963
CAS No.: 2640567-43-5
Catalog No.: PC-72521Not For Human Use, Lab Use Only.
INE963 (INE-963) is a potent and fast-acting blood-stage antimalarial, demonstrates potent cellular activity against Pf 3D7 with EC50 of 6 nM in Pf growth inhibition assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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INE963 (INE-963) is a potent and fast-acting blood-stage antimalarial, demonstrates potent cellular activity against Pf 3D7 with EC50 of 6 nM in Pf growth inhibition assay.
INE963 displays excellent antiplasmodium potency, selectivity against human kinases, and absorption, distribution, metabolism, excretion, and toxicity properties and extended pharmacological profiles.
A single dose of INE963 (30 mg/kg) is fully curative in the Pf-humanized severe combined immunodeficient mouse model.
INE963 exhibits a high barrier to resistance in drug selection studies and a long half-life (T1/2) across species.
| M.Wt | 402.517 | |
| Formula | C19H26N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(aminomethyl)-1-(5-(6-isopropyl-2-methoxypyridin-3-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)piperidin-4-ol |
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1. Benjamin R. Taft, et al. ACS Med. Chem. Lett. 2022
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