| Cat. No. |
Product Name |
Information |
| PC-45379 |
Mebendazole
|
Mebendazole is a highly effective, broad-spectrum antihelmintic by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells.. |
| PC-45158 |
Doramectin
Antibiotic
|
Doramectin is a derivative of ivermectin that approved for the treatment of parasites, is an active compound against S.mansoni in an NMRI mouse infection model. |
| PC-42044 |
NSC5844
Antimalarial
|
NSC5844 (RE-640) is a bis-quinoline with diverse biological activities, inhibits the growth of P. falciparum strains that are sensitive (D-6) and resistant (W-2) to chloroquine with IC50 of 17 and 27 nM, respectively. |
| PC-27570 |
WHZ-13
Pf20S inhibitor
|
WHZ-13 is a potent, selective P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 4.1 nM for Pf20S β5, has 91-fold and 24-fold selectivity over β5c and β5i, shows antimalarial EC50 of 3.1 nM against Pf 3D7. |
| PC-27569 |
WHZ-04
Pf20S inhibitor
|
WHZ-04 is a potent, selective P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 20.8 nM for Pf20S β5, has 68-fold and 4.8-fold selectivity over β5c and β5i, shows antimalarial EC50 of 8.4 nM against Pf 3D7. |
| PC-27568 |
MPI-13
Pf20S inhibitor
|
MPI-13 is a potent, covalent, orally bioavailable P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 12 nM, 230 nM and 24 nM for Pf20S β5, Hs20S β5c and Hs20S β5i respectively, exhibits fast-acting antimalarial activity with LD50 of 11 nM for Pf 3D7 strain. |
| PC-27567 |
MPI-5
Pf20S inhibitor
|
MPI-5 is a potent, covalent, reversible P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 2 nM, 85 nM and 24 nM for Pf20S β5, Hs20S β5c and Hs20S β5i respectively, exhibits fast-acting antimalarial activity with LD50 of 21 nM for Pf 3D7 strain. |
| PC-27566 |
MPI-1
Pf20S inhibitor
|
Malaria Proteasome Inhibitor-1 (MPI-1) is a potent, covalent, reversible P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 160 nM, 154 nM and 28 nM for Pf20S β5, Hs20S β5c and Hs20S β5i respectively, exhibits fast-acting antimalarial activity with LD50 of 55 nM for Pf 3D7 strain. |
| PC-27565 |
TDI6245
Pf20S inhibitor
|
TDI6245 (TDI-6245) is a highly potent Plasmodium 20S proteasome core (Pf20S) β5 inhibitor with IC50 of 110 nM, shows potent anti-Pf 3D7 activity with EC50 of 38 nM, has >60 fold selectivity over human c-20S β5c and human i-20S β5i. |
| PC-27564 |
TDI4258
Pf20S inhibitor
|
TDI4258 (TDI-4258) is a highly potent Plasmodium 20S proteasome core (Pf20S) β5 inhibitor with IC50 of 81 nM, shows potent anti-Pf 3D7 activity with EC50 of 17 nM, has >100-fold selectivity over human c-20S β5c and human i-20S β5i. |
| PC-27481 |
Nisaclaner
Antiparasitic
|
Nisaclaner is an antiparasite compound against parasitic infestations of fish. |
| PC-27252 |
PfHsp70-1 inhibitor AMK4
PfHsp70-1 inhibitor
|
PfHsp70-1 inhibitor AMK4 is a selective inhibitor of Plasmodium falciparum chaperone PfHsp70-1 with MST Kd of 41 uM,binds to substrate-binding domain (SBD) and leads to disruption in peptide binding, has >25-fold for PfHsp70-1 over the human homolog HSPA1A. |
