| Cat. No. |
Product Name |
Information |
| PC-45409 |
Pyrimethamine
NRF2 inhibitor
|
Pyrimethamine (Pirimetamin, RP 4753) is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties, interferes with the regeneration of tetrahydrofolic acid from dihydrofolate by competitively inhibiting DHFR, also is a potent NRF2 inhibitor. |
| PC-42397 |
Emodepside
Anthelmintic
|
Emodepside (PF 1022-221) is a semisynthetic derivative of PF1022A, and novel cyclo-depsipeptide anthelmintic which is efficacious against a variety of gastrointestinal nematodes. |
| PC-45382 |
Rafoxanide
Antiparasite, SPAK inhibitor
|
Rafoxanide is a salicylanilide anthelmintic agent that also shows to be an allosteric inhibitor of SPAK and OSR1. |
| PC-45368 |
Buparvaquone
Antiprotozoal
|
Buparvaquone is a hydroxynaphthoquinone antiprotozoal drug related to parvaquone and atovaquone. |
| PC-45379 |
Mebendazole
|
Mebendazole is a highly effective, broad-spectrum antihelmintic by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells.. |
| PC-45158 |
Doramectin
Antibiotic
|
Doramectin is a derivative of ivermectin that approved for the treatment of parasites, is an active compound against S.mansoni in an NMRI mouse infection model. |
| PC-42044 |
NSC5844
Antimalarial
|
NSC5844 (RE-640) is a bis-quinoline with diverse biological activities, inhibits the growth of P. falciparum strains that are sensitive (D-6) and resistant (W-2) to chloroquine with IC50 of 17 and 27 nM, respectively. |
| PC-27957 |
Triclabendazole
Anthelmintic agent
|
Triclabendazole is an anthelmintic agent that is tuniquely effective against both mature and immature stages of the liver flukes Fasciola hepatica and Fasciola gigantica, inhibits succinate dehydrogenase (SDH) in mitochondria of the cestode Echinococcus multilocularis, disrupts mitochondrial electron transport in vitro. |
| PC-27936 |
BKI-1
PfCDPK4 inhibitor
|
BKI-1 (Bumped Kinase Inhibitor-1) is a highly potent bumped kinase inhibitor with IC50 of 4 nM for WT rPfCDPK4, potently inhibits the exflagellation of P. falciparum, does not block the proliferation of asexual parasites. |
| PC-27570 |
WHZ-13
Pf20S inhibitor
|
WHZ-13 is a potent, selective P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 4.1 nM for Pf20S β5, has 91-fold and 24-fold selectivity over β5c and β5i, shows antimalarial EC50 of 3.1 nM against Pf 3D7. |
| PC-27568 |
MPI-13
Pf20S inhibitor
|
MPI-13 is a potent, covalent, orally bioavailable P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 12 nM, 230 nM and 24 nM for Pf20S β5, Hs20S β5c and Hs20S β5i respectively, exhibits fast-acting antimalarial activity with LD50 of 11 nM for Pf 3D7 strain. |
| PC-27567 |
MPI-5
Pf20S inhibitor
|
MPI-5 is a potent, covalent, reversible P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 2 nM, 85 nM and 24 nM for Pf20S β5, Hs20S β5c and Hs20S β5i respectively, exhibits fast-acting antimalarial activity with LD50 of 21 nM for Pf 3D7 strain. |
