| Cat. No. |
Product Name |
Information |
| PC-27443 |
RUPB-61
PfPKG inhibitor
|
RUPB-61 is a potent, selective and orally bioavailable inhibitor of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) with IC50 of 13 nM, EC50 of 50 uM against multi-drug resistant P. falciparum lab strain 3D7, blocks sporozoite infection of the liver. |
| PC-27209 |
CWHM-1008
Antimalarial
|
CWHM-1008 is a potent, orally efficacious antimalarial agent with EC50 values of 46 nM and 21 nM against drug sensitive Plasmodium falciparum 3D7 and drug resistant Dd2 strains, respectively. |
| PC-27175 |
UCB-9721
TgMyoA inhibitor
|
UCB-9721 is a potent inhibitor of T. gondii MyoA (TgMyoA) with IC50 of 31 nM, a class XIV myosin motor of apicomplexan parasites, inhibits TgMyoA actin-activated ATPase activity. |
| PC-26128 |
Cruzidione
T. cruzi inhibitor
|
Cruzidione is a potent anti-T. cruzi activity and anti-Chagas compound with anti-trypanosomal activity with IC50 of 3.65 uM. |
| PC-25293 |
LXE408
Kinetoplastid proteasome inhibitor
|
Galeflaprit (LXE408) is a potent, selective inhibitor of the kinetoplastid proteasome with IC50 of 0.04 uM (L. donovani proteasome), inhibits L. donovani amastigote proliferation within primary mouse macrophages (IC50=0.04 uM). |
| PC-25200 |
BKI-1708
CpCDPK1 inhibitor
|
BKI-1708 is a highly potent, specific Cryptosporidium calcium-dependent protein kinase 1 (CDPK1) inhibitor with IC50 of 0.7 nM (CpCDPK1, C. parvum CDPK1) and EC50 of 0.4 uM against C. parvum parasites in Nanoluciferase assays. |
| PC-25005 |
ZY-19489
Antimalarial
|
Sutidiazine (Zintrodiazine, ZY-19489, MMV 253, AZ-13721412) is a novel antimalarial triaminopyrimidine compound with IC50 of 9 nM against sexual blood stage of Plasmodium falciparum (Pf). |
| PC-24759 |
BKI-1748
CDPK1 inhibitor
|
BKI-1748 a small molecule bumped kinase inhibitor targeting calcium dependent protein kinase 1 (CDPK1), inhibits TgCDPK1 and NcCDPK1 enzyme activities at low nM-concentrations, inhibits proliferation of apicomplexan parasites with EC50 of 165 nM for N. caninum and 43 nM for T. gondii. |
| PC-23131 |
EDI048
Cryptosporidium PI4K inhibitor
|
EDI048 (EDI-048) is a specific, ATP-competitive, gastrointestinal-targeted Cryptosporidium PI(4)K (CpPI(4)K) inhibitor with IC50 of 4 nM, >300-fold with human orthologue HsPI(4)K, demonstrates in vitro anti-Cryptosporidium activity (Cp CPE, EC50=52 nM). |
| PC-22969 |
UCT594
Pf PI4K inhibitor
|
UCT594 is a highly potent, selective Plasmodium phosphatidylinositol 4-kinase (PI4K) inhibitor, inhibits the P. vivax PI4K enzyme with IC50 of 24 nM, >200-fold selective over human PI4Kβ ortholog. |
| PC-22800 |
SW584
Pf20Sβ5 inhibitor
|
SW584 is a potent, species-selective, orally active inhibitor of P. falciparum proteasome β5 active site (Pf20Sβ5) with IC50 of 5.8 nM, shows antimalarial activity with EC50 of 3 nM (Pf3D7 and PfDd2). |
| PC-22743 |
MMV1580853
Antimalarial
|
MMV1580853 (BPH-1358) is a potent and exceedingly fast-acting blood-stage antimalarial, inhibits human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, is active against S. aureus in vitro (MIC, 250 ng/mL). |
