Catalog No.: PC-25928Not For Human Use, Lab Use Only.
IID432 (IID-432) is a highly potent inhibitor of Trypanosoma cruzi topoisomerase II (T. cruzi Topo II), shows potent activity against T. cruzi with EC50 of 8 nM.
IID432 (IID-432) is a highly potent, covalent inhibitor of Trypanosoma cruzi topoisomerase II (T. cruzi Topo II), shows potent activity against T. cruzi with EC50 of 8 nM.
IID432 shows covalently engaging a parasite-specific cysteine (Cys477), thereby conferring selectivity over the human TOP2A.
IID432 displays favorable oral pharmacokinetics, with no off-target activity on human topoisomerases.
IID432 rapidly induces parasite-specific DNA damage and produces sterilizing activity in vitro and in vivo without recrudescence.
