Chemical Structure : RUPB-61
CAS No.:
RUPB-61
(RUPB61)
Catalog No.: PC-27443Not For Human Use, Lab Use Only.
RUPB-61 is a potent, selective and orally bioavailable inhibitor of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) with IC50 of 13 nM, EC50 of 50 uM against multi-drug resistant P. falciparum lab strain 3D7, blocks sporozoite infection of the liver.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RUPB-61 is a potent, selective and orally bioavailable inhibitor of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) with IC50 of 13 nM, EC50 of 50 uM against multi-drug resistant P. falciparum lab strain 3D7, blocks sporozoite infection of the liver.
RUPB-61 prevents infection by P. falciparum and P. cynomolgi sporozoites.
RUPB-61 is efficacious in murine model of liver infection, block sporozoite invasion of hepatocytes.
RUPB-61 has moderate selectivity for human kinases ROCK1 and EGFR.
Physicochemical Properties
|
M.Wt
|
348.47
|
|
Formula
|
C23H25FN2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(3S,4S)-4-(5-(4-fluorophenyl)-4-phenyl-1H-pyrrol-2-yl)-1,3-dimethylpiperidine
|
References
1. Dhiyebi H, et al. PLoS Pathog. 2026 Jul 30;22(7):e1014322.
Contact Us
sales@probechem.com
