LXE408 | Kinetoplastid proteasome inhibitor

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Chemical Structure : LXE408

CAS No.: 1799330-15-6

LXE408 (LXE-408)

Catalog No.: PC-25293Not For Human Use, Lab Use Only.

LXE408 is a potent, selective inhibitor of the kinetoplastid proteasome with IC50 of 0.04 uM (L. donovani proteasome), inhibits L. donovani amastigote proliferation within primary mouse macrophages (IC50=0.04 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Physicochemical Properties

M.Wt	443.44
Formula	C23H18FN7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-Fluoro-3-(6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl)-2,4-dimethyloxazole-5-carboxamide

References

1. Nagle A, et al. J Med Chem. 2020 Oct 8;63(19):10773-10781.

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LXE408 (LXE-408)

Biological Activity

Physicochemical Properties

References

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