| Cat. No. |
Product Name |
Information |
| PC-21577 |
OJT008
Mtb MetAP1 inhibitor
|
OJT008 is a small molecule Mtb. MetAP inhibitor against M. tuberculosis, has MIC50 of 0.063 µg/mL against both active and MDR Mtb. |
| PC-21553 |
TDI-8304
Pf20S inhibitor
|
TDI-8304 is a highly selective, macrocyclic peptide inhibitor of malaria parasite Plasmodium falciparum proteasome (Pf20S) with IC50 of 0.06 uM, shows high potency against P. falciparum strain Pf 3D7 (EC50=0.009 uM). |
| PC-21550 |
DNDI-6174
Cyt bc1 inhibitor
|
DNDI-6174 is a highly potent inhibitor of Leishmania cytochrome bc1 complex activity, shows broad activity against a panel of representative visceral leishmaniasis clinical isolates from various sources (EC50=10-360 nM). |
| PC-21539 |
MMV693183
Antiparasite
|
MMV693183 is a first-in-class acetyl-CoA synthetase (AcAS) inhibitor and potent antimalarial drug candidate (Asexual blood stage IC50=2.1-2.8 nM). |
| PC-21445 |
CZC-54252
Anti-parasite
|
CZC-54252 is a small molecule inhibitor of five P. falciparum kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB with IC50 of 3.4, 1.8, 1.0, 1.2 and 0.07 uM, respectively. |
| PC-21377 |
Antitrypanosomal agent 10
Antitrypanosomal
|
Antitrypanosomal agent 10 is a potent, orally active antitrypanosomal compound, selectively inhibits the growth of parasites T. b. brucei, T. b. gambiense and T. b. rhodesiense with EC50 of 0.54, 0.13 and 1.14 uM, resepctively. |
| PC-21135 |
IMP-1002
NMT inhibitor
|
IMP-1002 (IMP1002) is a potent P. falciparum N-myristoyltransferase (PfNMT) inhibitor, potently inhibits parasite growth with EC50 of 34 nM (3D7 strain). |
| PC-21094 |
WEHI-518
PfPI4KIIIB inhibitor
|
WEHI-518 is a small molecule inhibitor of the parasite's phosphatidylinositol kinase PfPI4KIIIB, shows EC50 of 22 nM against blood-stage P. falciparum parasites. |
| PC-21087 |
MMV396797
PfPI4KIIIB inhibitor
|
MMV396797 is a small molecule inhibitor of the parasite's phosphatidylinositol kinase PfPI4KIIIB, block parasite protein secretion and export. |
| PC-20947 |
Cyanotriazole CT3
Parasite Topo II inhibitor
|
Cyanotriazole CT3 is a potent, selective, irreversible inhibitor of trypanosomal topoisomerase II, shows potent trypanocidal activity both in vitro and in vivo. |
| PC-20941 |
JC-229
TbRPA1 inhibitor
|
JC-229 is a small-molecule inhibitor that selectively blocks DNA-binding by Trypanosoma brucei replication protein A1 (TbRPA1), exhibits growth inhibition of T. brucei with EC50 of 6.6 uM. |
| PC-20587 |
ML276
PfG6PDH inhibitor
|
ML276 (ML 276) is a potent, selective inhibitor of Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PDH) with IC50 of 889 nM, with no activity against human G6PD. |
