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Chemical Structure : Fanotaprim
CAS No.: 2120282-75-7
Catalog No.: PC-38359Not For Human Use, Lab Use Only.
Fanotaprim (VYR-006) is a potent, selective Toxoplasma gondii DHFR (TgDHFR) inhibitor with IC50 of 1.6 nM, 200-fold selectivity over human DHFR (hDHFR), shows anti-parasiticidal activity in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Fanotaprim (VYR-006) is a potent, selective Toxoplasma gondii DHFR (TgDHFR) inhibitor with IC50 of 1.6 nM, 200-fold selectivity over human DHFR (hDHFR), shows anti-parasiticidal activity in vitro and in vivo.
Fanotaprim (VYR-006) demonstrated a parasiticidal EC50 of 13 nM against the type I RH strain of T. gondii.
Fanotaprim (VYR-006) was effective in radical cure of acute infection with the highly virulent type I RH strain in the murine model showed similar potency across multiple parasite lineages in cell-based parasite growth assays.
| M.Wt | 378.440 | |
| Formula | C19H22N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(4-(3-(2-Methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine |
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1. Allen T Hopper, et al. J Med Chem. 2019 Feb 14;62(3):1562-1576.
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