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SBI-0797750

Chemical Structure : SBI-0797750

CAS No.: 3046154-77-9

SBI-0797750 (SBI 0797750)

Catalog No.: PC-72936Not For Human Use, Lab Use Only.

SBI-0797750 (SBI 0797750) is a potent, fully selective PfGluPho inhibitor with robust nanomolar activity against recombinant PfGluPho, PvG6PD, and P. falciparum blood-stage parasites.

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    Biological Activity

    SBI-0797750 (SBI 0797750) is a potent, fully selective PfGluPho inhibitor with robust nanomolar activity against recombinant PfGluPho, PvG6PD, and P. falciparum blood-stage parasites.
    SBI-0797750 disturbs the cytosolic glutathione-dependent redox potential, as well as the cytosolic and mitochondrial H2O2 homeostasis of P. falciparum blood stages, at low nanomolar concentrations.
    SBI-0797750 does not harm red blood cell (RBC) integrity and phagocytosis and thus does not promote anemia.

    Physicochemical Properties

    M.Wt 455.548
    Formula C24H26FN3O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(((2R,4S)-1-cyclobutyl-4-hydroxypyrrolidin-2-yl)methyl)-6-fluoro-4-methyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide

    References

    1. Isabell Berneburg, et al. Antimicrob Agents Chemother. 2022 Mar 10;e0210921.

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