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M5717

Chemical Structure : M5717

CAS No.: 1469439-69-7

M5717 (Cabamiquine, M 5717, DDD107498)

Catalog No.: PC-72956Not For Human Use, Lab Use Only.

Cabamiquine (DDD107498, M5717) is a potent, specific P. falciparum translation elongation factor 2 inhibitor (PfeEF2).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Cabamiquine (DDD107498, M5717) is a potent, specific P. falciparum translation elongation factor 2 inhibitor (PfeEF2).
M5717 demonstrated through high potency against asexual blood-stage P. falciparum parasites as well as in vivo by means of the well-established P. falciparum SCID mouse model.

Physicochemical Properties

M.Wt 462.569
Formula C27H31FN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-fluoro-2-(4-(morpholinomethyl)phenyl)-N-(2-(pyrrolidin-1-yl)ethyl)quinoline-4-carboxamide

References

1. Arez F, et al. ACS Infect Dis. 2019 Nov 8;5(11):1831-1842.

2. Rottmann M, et al. Antimicrob Agents Chemother. 2020 Mar 24;64(4):e02181-19.

3. McCarthy JS, et al. Lancet Infect Dis. 2021 Dec;21(12):1713-1724.

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