| Cat. No. |
Product Name |
Information |
| PC-27033 |
PfKRS1 inhibitor 30
PfKRS1 inhibitor
|
PfKRS1 inhibitor 30 is a potent selective inhibitor of P. falciparum lysyl-tRNA synthetase (PfKRS1) with pIC50 of 6.9, >1,000-fold selectivity for PfKRS1 over the human enzyme, exhibits potency against Pfalciparum (3D7) asexual blood stage with EC50 of 6 nM. |
| PC-26852 |
SLU-2633
Cryptosporidium parvum inhibitor
|
SLU-2633 is an orally efficacious anticryptosporidial triazolopyridazine with EC50 of 0.17 uM against Cryptosporidium parvum, exhibits fast-killing anticryptosporidial properties. |
| PC-26851 |
MMV665917
Cryptosporidium parvum inhibitor
|
MMV665917 is an orally active piperazine-based compound with high selectivity for the blood stages of malaria parasites and for Cryptosporidium species (Cryptosporidium parvum, EC90=15 uM). |
| PC-26820 |
Borrelidin
Threonyl-tRNA synthetase inhibitor
|
Borrelidin is a small molecule nitrile-containing macrolide inhibitor of bacterial and eukaryal threonyl-tRNA synthetase (ThrRS), inhibits protein synthesis, also shows stage-specific growth inhibition for Plasmodium falciparum. |
| PC-26689 |
WIN 4-88
CpCDPK1 inhibitor
|
WIN 4-88 is a potent small molecule inhibitor of Cryptosporidium parvum Calcium-dependent protein kinase 1 (CpCDPK1) with IC50 of 56 nM, exhibits growth inhibition of zoonotic C. parvum, anthroponotic C. parvum and C. hominis Tu502 with EC50 of 42, 30 and 62 nM respectively. |
| PC-26680 |
P218 hydrochloride
PfDHFR inhibitor
|
P218 hydrochloride is a highly potent inhibitor of Plasmodium falciparum dihydrofolate reductase (PfDHFR) with Ki of 0.54 nM for quadruple mutant P. falciparum DHFR, inhibits wild-type P. falciparum (TM4) and quadruple mutant P. falciparum (V1/S) with IC50 of 4.6 nM and 56 nM. |
| PC-26679 |
PfDHFR inhibitor P218
PfDHFR inhibitor
|
PfDHFR inhibitor P218 is a highly potent inhibitor of Plasmodium falciparum dihydrofolate reductase (PfDHFR) with Ki of 0.54 nM for quadruple mutant P. falciparum DHFR, inhibits wild-type P. falciparum (TM4) and quadruple mutant P. falciparum (V1/S) with IC50 of 4.6 nM and 56 nM. |
| PC-26662 |
DNDI-6148
Visceral leishmaniasis inhibitor
|
DNDI-6148 is a potent, selective inhibitor of Visceral leishmaniasis (VL) with EC50 of 1.8 uM and 1.4 uM for intramacrophage L. infantum and L. donovani, inhibits Leishmania cleavage and polyadenylation specificity factor (CPSF3) endonuclease. |
| PC-26449 |
VU041
Mosquito Kir1 inhibitor
|
VU041 is a selective inhibitor of mosquito Anopheles (An.) gambiae and Aedes (Ae.) aegypti inward rectifier potassium (Kir) channels with IC50 of 496 nM for AnKir1. |
| PC-26326 |
AN11736
Antiparasitic
|
AN11736 is a potent small molecule inhibitor of Trypanosoma congolense (T. congolense) and Trypanosoma vivax (T. vivax) parasites with IC50 of 0.15 nM and 1.3 nM respectively. |
| PC-26325 |
Enfiborole
Antiparasitic
|
Enfiborole is a potent small molecule inhibitor of Trypanosoma congolense (T. congolense) and Trypanosoma vivax (T. vivax) parasites with IC50 of 0.14 nM and 0.07 nM respectively. |
| PC-26055 |
MMV1581361
PfATP4 inhibitor
|
MMV1581361 is a potent inhibitor of Plasmodium falciparum ATP4 (PfATP4), inhibits 3D7 P. falciparum Strain with IC50 of 0.03 uM, disrupts Na+ ion homeostasis in P. falciparum. |
