| Cat. No. |
Product Name |
Information |
| PC-23310 |
Jaspamycin
TbPKA inhibitor, MTA3 inhibitor
|
Jaspamycin (7-CN-7-C-Ino) is a potent activator of Trypanosoma brucei PKA (TbPKA), binding to the R site (PKAR) with EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei, also inhibits hepatocellular carcinoma progression via trageting metastasis-associated protein 3 (MTA3). |
| PC-23296 |
JCP174
TgPPT1 inhibitor
|
JCP174 is a small molecule inhibitor of Toxoplasma gondii palmitoyl-protein thioesterase-1 (TgPPT1), enhances Toxoplasma host-cell invasion, triggers secretion of invasion-associated organelles, increases motility and enhances the invasive capacity of tachyzoites. |
| PC-23278 |
Artemisinin
PfPI3K inhibitor
|
Artemisinin (Qinghaosu) is a sesquiterpene lactone, an anti-malarial agent isolated from the aerial parts of Artemisia annua L., potently inhibits PfPI3K. |
| PC-23277 |
PfCLK3 inhibitor 4
PfCLK3 inhibitor
|
PfCLK3 inhibitor 4 is a potent, covalent inhibitor of Plasmodium falciparum CLK3 kinase (PfCLK3) with pIC50 of 8.02, covalently targets of PfCLK3 cys368, exhibits parasiticidal activity in P. falciparum 3D7 cell line with pEC50 of 7.1. |
| PC-23268 |
DDD508
CpKRS inhibitor
|
DDD508 is a potent, selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 of 1.7 uM, and C. parvum EC50 of 0.13 uM, shows anti-cryptosporidials activity. |
| PC-23267 |
DDD489
CpKRS inhibitor
|
DDD489 is a potent, selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 of 0.85 uM, and C. parvum EC50 of 0.04 uM, shows anti-cryptosporidials activity. |
| PC-23225 |
AR102
Schistosomes inhibitor
|
AR102 is a potent, selective, and broad-spectrum activity against schistosome species. |
| PC-23030 |
MMV665806
Falcilysin inhibitor, Antimalarial
|
MMV665806 is a small molecule antimalarial compound, bind to falcilysin (FLN) with KD of 7.33 uM and inhibits FLN proteolytic activity with IC50 of 5.9 uM. |
| PC-23029 |
MMV000848
Falcilysin inhibitor, PfPNP inhibitor
|
MMV000848 is a small molecule inhibitor of P. falciparum purine nucleoside phosphorylase (PfPNP, KD=1.52 uM) with EC50 of 0.1 uM against Plasmodium falciparum, also inhibits falcilysin (FLN) proteolytic activity. |
| PC-23028 |
MK-4815 hydrochloride
Falcilysin inhibitor, Antimalarial
|
MK-4815 hydrochloride is an orally active small molecule with antimalarial activity, inhibits P. falciparum 3D7 growth with IC50 of 0.03 ug/mL, inhibits falcilysin (FLN) proteolytic activity. |
| PC-23027 |
MK-4815
Falcilysin inhibitor, Antimalarial
|
MK-4815 is an orally active small molecule with antimalarial activity, inhibits P. falciparum 3D7 growth with IC50 of 0.03 ug/mL, inhibits falcilysin (FLN) proteolytic activity. |
| PC-22800 |
SW584
Pf20Sβ5 inhibitor
|
SW584 is a potent, species-selective, orally active inhibitor of P. falciparum proteasome β5 active site (Pf20Sβ5) with IC50 of 5.8 nM, shows antimalarial activity with EC50 of 3 nM (Pf3D7 and PfDd2). |
