| Cat. No. |
Product Name |
Information |
| PC-27566 |
MPI-1
Pf20S inhibitor
|
Malaria Proteasome Inhibitor-1 (MPI-1) is a potent, covalent, reversible P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 160 nM, 154 nM and 28 nM for Pf20S β5, Hs20S β5c and Hs20S β5i respectively, exhibits fast-acting antimalarial activity with LD50 of 55 nM for Pf 3D7 strain. |
| PC-27565 |
TDI6245
Pf20S inhibitor
|
TDI6245 (TDI-6245) is a highly potent Plasmodium 20S proteasome core (Pf20S) β5 inhibitor with IC50 of 110 nM, shows potent anti-Pf 3D7 activity with EC50 of 38 nM, has >60 fold selectivity over human c-20S β5c and human i-20S β5i. |
| PC-27564 |
TDI4258
Pf20S inhibitor
|
TDI4258 (TDI-4258) is a highly potent Plasmodium 20S proteasome core (Pf20S) β5 inhibitor with IC50 of 81 nM, shows potent anti-Pf 3D7 activity with EC50 of 17 nM, has >100-fold selectivity over human c-20S β5c and human i-20S β5i. |
| PC-27481 |
Nisaclaner
Antiparasitic
|
Nisaclaner is an antiparasite compound against parasitic infestations of fish. |
| PC-27252 |
PfHsp70-1 inhibitor AMK4
PfHsp70-1 inhibitor
|
PfHsp70-1 inhibitor AMK4 is a selective inhibitor of Plasmodium falciparum chaperone PfHsp70-1 with MST Kd of 41 uM,binds to substrate-binding domain (SBD) and leads to disruption in peptide binding, has >25-fold for PfHsp70-1 over the human homolog HSPA1A. |
| PC-27251 |
PfHsp70-1 inhibitor AMK3
PfHsp70-1 inhibitor
|
PfHsp70-1 inhibitor AMK3 is a potent, high affinity and selective inhibitor of Plasmodium falciparum chaperone PfHsp70-1 with MST Kd of 0.82 uM, binds to the PfHsp70-1 N-terminal NBD and competes for ATP binding, has >25-fold for PfHsp70-1 over the human homolog HSPA1A. |
| PC-27181 |
MMV022224
PfPK6 inhibitor
|
MMV022224 (TCMDC-132409) is a potent inhibitor of P. falciparum in vitro with low resistance, targets P. falciparum protein kinase 6 (PfPK6) with IC50 of 0.8 uM. |
| PC-27176 |
VEST19
TgMyoA inhibitor
|
VEST19 is a potent inhibitor of T. gondii MyoA (TgMyoA) with IC50 of 70 nM, a class XIV myosin motor of apicomplexan parasites, inhibits TgMyoA actin-activated ATPase activity, inhibits the growth of T. gondii in human foreskin fibroblasts (HFFs) with IC50 of 0.366 uM. |
| PC-27146 |
Artesunate
P. falciparum EXP1 inhibitor, STAT3 inhibitor
|
Artesunate is an antimalarial and potent, hematin-dependent inhibitor of P. falciparum exported protein 1 (EXP1, PfMGST) with IC50 of 2.05 nM, inhibits EXP1 glutathione transferase activity toward hematin, also is a potential inhibitor of STAT-3. |
| PC-27145 |
Artemether
Antimalarial
|
Artemether is a potent and rapidly acting blood schizontocide, interferes with the growth of parasites in the red blood cells of the human body, is a semi-synthetic derivative of artemisinin. |
| PC-27144 |
Praziquantel
Anthelmintic
|
Praziquantel (Embay 8440) is an orally active, broadly effective anthelmintic for trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. |
| PC-27143 |
DW-3-15
Antischistosomal
|
DW-3-15 is a praziquantel and artesunate conjugate and effective anti-schistosomal agent, inhibits both juvenile and adult Schistosoma japonicumin through SjHAT1 inhibition, exhibits good worm killing activity both in vitro and in vivo. |
