| Cat. No. |
Product Name |
Information |
| PC-27957 |
Triclabendazole
Anthelmintic agent
|
Triclabendazole is an anthelmintic agent that is tuniquely effective against both mature and immature stages of the liver flukes Fasciola hepatica and Fasciola gigantica, inhibits succinate dehydrogenase (SDH) in mitochondria of the cestode Echinococcus multilocularis, disrupts mitochondrial electron transport in vitro. |
| PC-27936 |
BKI-1
PfCDPK4 inhibitor
|
BKI-1 (Bumped Kinase Inhibitor-1) is a highly potent bumped kinase inhibitor with IC50 of 4 nM for WT rPfCDPK4, potently inhibits the exflagellation of P. falciparum, does not block the proliferation of asexual parasites. |
| PC-27570 |
WHZ-13
Pf20S inhibitor
|
WHZ-13 is a potent, selective P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 4.1 nM for Pf20S β5, has 91-fold and 24-fold selectivity over β5c and β5i, shows antimalarial EC50 of 3.1 nM against Pf 3D7. |
| PC-27568 |
MPI-13
Pf20S inhibitor
|
MPI-13 is a potent, covalent, orally bioavailable P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 12 nM, 230 nM and 24 nM for Pf20S β5, Hs20S β5c and Hs20S β5i respectively, exhibits fast-acting antimalarial activity with LD50 of 11 nM for Pf 3D7 strain. |
| PC-27567 |
MPI-5
Pf20S inhibitor
|
MPI-5 is a potent, covalent, reversible P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 2 nM, 85 nM and 24 nM for Pf20S β5, Hs20S β5c and Hs20S β5i respectively, exhibits fast-acting antimalarial activity with LD50 of 21 nM for Pf 3D7 strain. |
| PC-27566 |
MPI-1
Pf20S inhibitor
|
Malaria Proteasome Inhibitor-1 (MPI-1) is a potent, covalent, reversible P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 160 nM, 154 nM and 28 nM for Pf20S β5, Hs20S β5c and Hs20S β5i respectively, exhibits fast-acting antimalarial activity with LD50 of 55 nM for Pf 3D7 strain. |
| PC-27565 |
TDI6245
Pf20S inhibitor
|
TDI6245 (TDI-6245) is a highly potent Plasmodium 20S proteasome core (Pf20S) β5 inhibitor with IC50 of 110 nM, shows potent anti-Pf 3D7 activity with EC50 of 38 nM, has >60 fold selectivity over human c-20S β5c and human i-20S β5i. |
| PC-27564 |
TDI4258
Pf20S inhibitor
|
TDI4258 (TDI-4258) is a highly potent Plasmodium 20S proteasome core (Pf20S) β5 inhibitor with IC50 of 81 nM, shows potent anti-Pf 3D7 activity with EC50 of 17 nM, has >100-fold selectivity over human c-20S β5c and human i-20S β5i. |
| PC-27481 |
Nisaclaner
Antiparasitic
|
Nisaclaner is an antiparasite compound against parasitic infestations of fish. |
| PC-27252 |
PfHsp70-1 inhibitor AMK4
PfHsp70-1 inhibitor
|
PfHsp70-1 inhibitor AMK4 is a selective inhibitor of Plasmodium falciparum chaperone PfHsp70-1 with MST Kd of 41 uM,binds to substrate-binding domain (SBD) and leads to disruption in peptide binding, has >25-fold for PfHsp70-1 over the human homolog HSPA1A. |
| PC-27251 |
PfHsp70-1 inhibitor AMK3
PfHsp70-1 inhibitor
|
PfHsp70-1 inhibitor AMK3 is a potent, high affinity and selective inhibitor of Plasmodium falciparum chaperone PfHsp70-1 with MST Kd of 0.82 uM, binds to the PfHsp70-1 N-terminal NBD and competes for ATP binding, has >25-fold for PfHsp70-1 over the human homolog HSPA1A. |
| PC-27181 |
MMV022224
PfPK6 inhibitor
|
MMV022224 (TCMDC-132409) is a potent inhibitor of P. falciparum in vitro with low resistance, targets P. falciparum protein kinase 6 (PfPK6) with IC50 of 0.8 uM. |
