| Cat. No. |
Product Name |
Information |
| PC-22800 |
SW584
Pf20Sβ5 inhibitor
|
SW584 is a potent, species-selective, orally active inhibitor of P. falciparum proteasome β5 active site (Pf20Sβ5) with IC50 of 5.8 nM, shows antimalarial activity with EC50 of 3 nM (Pf3D7 and PfDd2). |
| PC-22744 |
MMV026468
Antimalarial
|
MMV026468 is a highly potent, picomolar inhibitor of blood-stage Plasmodium falciparum, targets MEP isoprenoid precursor biosynthesis, inhibits first MEP enzyme DXS or steps prior to DXS such as regulation of the MEP pathway. |
| PC-22690 |
MIPS2673
Parasite M1 aminopeptidase inhibitor
|
MIPS2673 is a potent selective inhibitor of Plasmodium M1 aminopeptidase with Ki of 211 nM and 6.4 nM for PfA-M1 and PvA-M1, demonstrates antimalarial activity against a panel of drug-resistant P. falciparum strains. |
| PC-22543 |
WEHI-991
PfSTART1 inhibitor
|
WEHI-991 (W-991) is a potent small molecule inhibitor of PfSTART1 with antiparasitic activity EC50 of 7 nM for Pf 3D7, binds to PfSTART1(WT) with KD of 10 nM, inhibits ring-stage development of Plasmodium falciparum. |
| PC-22542 |
MMV006833
PfSTART1 inhibitor
|
MMV006833 (M-833) is a small molecule inhibitor of PfSTART1 with EC50 of 1.1 uM for Pf 3D7, binds to PfSTART1(WT) with KD of 42 nM, inhibits ring-stage development of Plasmodium falciparum, prevents PfSTART1 from expanding the vacuole membrane encasing the parasite after red blood cell invasion, thereby blocking parasite growth. |
| PC-22515 |
ELQ-672
Antiparasite
|
ELQ-672 is a endochin-like quinolone compound with potent antibabesial activity with IC50 of 57 nM against B. duncani in human erythrocytes. |
| PC-22514 |
ELQ-598
Antiparasite
|
ELQ-598 is a endochin-like quinolone compound with potent antibabesial activity with IC50 of 37 nM against B. duncani in human erythrocytes, the prodrug of ELQ-596. |
| PC-22513 |
ELQ-596
Antiparasite
|
ELQ-596 is a endochin-like quinolone compound with potent antibabesial activity with IC50 of 32 nM against B. duncani in human erythrocytes. |
| PC-22374 |
DDD00057570
Aminopeptidase M17 inhibitor
|
DDD00057570 is a selective inhibitor of Leishmania major M17 leucyl-aminopeptidase (LAP) with IC50 of 3.3 uM, exhibits in vitro antileishmanial activity. |
| PC-22373 |
MMV1557817
Aminopeptidase M1/M17 inhibitor
|
MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 (Ki=308/19 nM) and M17 (Ki=112/208 nM), demonstrates potent activity against asexual and sexual stage parasites. |
| PC-22334 |
NPD8790
Complex I inhibitor
|
NPD8790 is a species-selective inhibitor of mitochondrial respiratory complex I with IC50 of 1.6, 2.1 and 1.1 uM for C. briggsae, P. pacificus and P. hermaphrodita complex I, respectively, does not inhibit human mitochondria with IC50 of >75 uM. |
| PC-21997 |
mCMY416
PheRS inhibitor
|
mCMY416 is a potent and selective inhibitor of Toxoplasma gondii phenylalanine tRNA synthetase (PheRS), potently inhibits T. gondii growth with EC90 of 0.38 uM. |
