Cruzipain inhibitor SH-1

Chemical Structure : Cruzipain inhibitor SH-1

Catalog No.: PC-23718Not For Human Use, Lab Use Only.

Cruzipain inhibitor SH-1 is a potent, selective and covalent cysteine protease Cruzipain (CZP) of Trypanosoma cruzi with IC50 of 28 nM, without inhibition on human cathepsin L.

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Biological Activity

Cruzipain inhibitor SH-1 is a potent, selective and covalent cysteine protease Cruzipain (CZP) of Trypanosoma cruzi with IC50 of 28 nM, without inhibition on human cathepsin L.
SH-1 forms a reversible covalent bond with Cys25 in CZP.
SH-1 demonstrates bioactivity translation comparable to that of K777 (1–10 μM).
SH-1 shows antitrypanosomal activity (IC50 = 6.67 μM).

Physicochemical Properties

M.Wt	418.51
Formula	C20H26N4O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-2-(4-(((benzo[d][1,3]dioxol-5-ylmethyl)amino)(cyclohexyl)methyl)-1H-1,2,3-triazol-1-yl)-3-mercaptopropanoic acid

References

1. Juan Pablo Cerutti, et al. ACS Medicinal Chemistry Letters, 2024. Dec.

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