Chemical Structure : PRC1590
CAS No.:
2715225-58-2
PRC1590
(PRC-1590)
Catalog No.: PC-23893Not For Human Use, Lab Use Only.
PRC1590 is a tetrahydro-β-carboline compound that potently kills the malaria parasite with EC50 of 145 nM and 142 nM in growth inhibition assays in 3D7WT and Dd2 strains.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PRC1590 is a tetrahydro-β-carboline compound that potently kills the malaria parasite with EC50 of 145 nM and 142 nM in growth inhibition assays in 3D7WT and Dd2 strains.
PRC1590 has a mechanism of action associated with P. falciparum's DV that differs from chloroquine, inhibits trophozoite stage.
The mechanism of resistance to PRC1590 is mediated by the G293V single-nucleotide polymorphism (SNP) of the P. falciparum multidrug resistance protein 1 (PfMDR1), a transporter located on the membrane of the digestive vacuole (DV).
Physicochemical Properties
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M.Wt
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505.80
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Formula
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C26H18BrClN2O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-(5-bromobenzofuran-2-yl)(1-(4-chlorophenyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)methanone
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References
1. Emily K Bremers, et al. ACS Infect Dis. 2025 Jan 14. doi: 10.1021/acsinfecdis.4c01001.
2. Hanan Almolhim, et al. ACS Med Chem Lett. 2022 Feb 24;13(3):371-376.
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