TAO inhibitor 1

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Chemical Structure : TAO inhibitor 1

Catalog No.: PC-24725Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TAO inhibitor 1 is a potent, selective trypanosome alternative oxidase (TAO) inhibitor with IC50/Ki of 1.3/3.46 nM (purified TAO), displays broad-spectrum activity against african animal trypanosomes.
TAO inhibitor 1 has single-digit nanomolar range against trypomastigotes of T. b. brucei, T. evansi, and T. equiperdum, including drug-resistant strains.
TAO inhibitor 1 demonstrates good safety toward mammalian cells in vitro (selectivity index >2300).

Physicochemical Properties

M.Wt	690.70
Formula	C39H49BrNO3P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	{14-[(4-Hydroxy-2-methylbenzoyl)oxy]tetradecyl}diphenyl(pyridin-2-yl)Phosphonium Bromide

References

1. Ebiloma GU, et al. J Med Chem. 2025 Jun 4. doi: 10.1021/acs.jmedchem.5c00631.

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TAO inhibitor 1

Biological Activity

Physicochemical Properties

References

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