| Cat. No. |
Product Name |
Information |
| PC-45380 |
Closantel
FICD inhibitor
|
Closantel (FICD inhibitor C22) is a veterinary anthelmintic with known proton ionophore activities, also is a small molecule inhibitor of the AMP transferase FICD with IC50 of 7.27 uM. |
| PC-45409 |
Pyrimethamine
NRF2 inhibitor
|
Pyrimethamine (Pirimetamin, RP 4753) is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties, interferes with the regeneration of tetrahydrofolic acid from dihydrofolate by competitively inhibiting DHFR, also is a potent NRF2 inhibitor. |
| PC-42397 |
Emodepside
Anthelmintic
|
Emodepside (PF 1022-221) is a semisynthetic derivative of PF1022A, and novel cyclo-depsipeptide anthelmintic which is efficacious against a variety of gastrointestinal nematodes. |
| PC-45382 |
Rafoxanide
Antiparasite, SPAK inhibitor
|
Rafoxanide is a salicylanilide anthelmintic agent that also shows to be an allosteric inhibitor of SPAK and OSR1. |
| PC-45368 |
Buparvaquone
Antiprotozoal
|
Buparvaquone is a hydroxynaphthoquinone antiprotozoal drug related to parvaquone and atovaquone. |
| PC-45379 |
Mebendazole
|
Mebendazole is a highly effective, broad-spectrum antihelmintic by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells.. |
| PC-45158 |
Doramectin
Antibiotic
|
Doramectin is a derivative of ivermectin that approved for the treatment of parasites, is an active compound against S.mansoni in an NMRI mouse infection model. |
| PC-42044 |
NSC5844
Antimalarial
|
NSC5844 (RE-640) is a bis-quinoline with diverse biological activities, inhibits the growth of P. falciparum strains that are sensitive (D-6) and resistant (W-2) to chloroquine with IC50 of 17 and 27 nM, respectively. |
| PC-26820 |
Borrelidin
Threonyl-tRNA synthetase inhibitor
|
Borrelidin is a small molecule nitrile-containing macrolide inhibitor of bacterial and eukaryal threonyl-tRNA synthetase (ThrRS), inhibits protein synthesis, also shows stage-specific growth inhibition for Plasmodium falciparum. |
| PC-26689 |
WIN 4-88
CpCDPK1 inhibitor
|
WIN 4-88 is a potent small molecule inhibitor of Cryptosporidium parvum Calcium-dependent protein kinase 1 (CpCDPK1) with IC50 of 56 nM, exhibits growth inhibition of zoonotic C. parvum, anthroponotic C. parvum and C. hominis Tu502 with EC50 of 42, 30 and 62 nM respectively. |
| PC-26680 |
P218 hydrochloride
PfDHFR inhibitor
|
P218 hydrochloride is a highly potent inhibitor of Plasmodium falciparum dihydrofolate reductase (PfDHFR) with Ki of 0.54 nM for quadruple mutant P. falciparum DHFR, inhibits wild-type P. falciparum (TM4) and quadruple mutant P. falciparum (V1/S) with IC50 of 4.6 nM and 56 nM. |
| PC-26679 |
PfDHFR inhibitor P218
PfDHFR inhibitor
|
PfDHFR inhibitor P218 is a highly potent inhibitor of Plasmodium falciparum dihydrofolate reductase (PfDHFR) with Ki of 0.54 nM for quadruple mutant P. falciparum DHFR, inhibits wild-type P. falciparum (TM4) and quadruple mutant P. falciparum (V1/S) with IC50 of 4.6 nM and 56 nM. |
