| Cat. No. |
Product Name |
Information |
| PC-23718 |
Cruzipain inhibitor SH-1
Cruzipain inhibitor
|
Cruzipain inhibitor SH-1 is a potent, selective and covalent cysteine protease Cruzipain (CZP) of Trypanosoma cruzi with IC50 of 28 nM, without inhibition on human cathepsin L. |
| PC-23717 |
DSM1465
PfDHODH inhibitor
|
DSM1465 is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with IC50 of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites in whole-cell assays with EC50 of 1.4 nM. |
| PC-23705 |
TKK129
Antimalarial
|
TKK129 is a 3-hydroxypropanamidine antimalarial inhibitor of IC50 of 2 nM (Pf3D7), shows excellent antiplasmodial in vitro activity against drug-sensitive and -resistant Plasmodium falciparum strains (IC50=6-16 nM). |
| PC-23704 |
TKK130
Antimalarial
|
TKK130 is a 3-hydroxypropanamidine antimalarial inhibitor of IC50 of 2 nM (Pf3D7), inhibits synthetic hemozoin (β-hematin) formation, shows excellent antiplasmodial in vitro activity against drug-sensitive and -resistant Plasmodium falciparum strains (IC50=2-12 nM). |
| PC-23695 |
SLU-10906
CpPDE1 inhibitor
|
SLU-10906 is a potent inhibitor of parasite Cryptosporidium with EC50 of 0.19 uM (Cp HCT-8 assay), selectively targets parasite phosphodiesterase CpPDE1. |
| PC-23663 |
MMV009108
PfNCR1 inhibitor
|
MMV009108 is a small molecule inhibitor of P. falciparum Niemann-Pick type C1-related (PfNCR1) transporter, hypersensitizes parasites to saponin. |
| PC-23658 |
SAL-0010042
P. falciparum PDEβ inhibitor
|
SAL-0010042 is a fast-acting and potent Plasmodium falciparum PDEβ inhibitor with IC50 of 10.8 nM for cGMP hydrolysis in crude gametocyte membrane preparations, and EC50 of 142 nM for 3D7 blood stage. |
| PC-23657 |
SAL-0010003
P. falciparum PDEβ inhibitor
|
SAL-0010003 is a fast-acting and potent Plasmodium falciparum PDEβ inhibitor with IC50 of 17.3 nM for cGMP hydrolysis in crude gametocyte membrane preparations, and EC50 of 327 nM for 3D7 blood stage. |
| PC-23626 |
TCDMC-143160
TcTDH inhibitor
|
TCDMC-143160 is a specific inhibitor of T. cruzi L-threonine dehydrogrenase (TcTDH) with IC50 of 3.5 uM, inhibits the threonine degradation pathway and interferes with parasite growth and viability. |
| PC-23600 |
ML901
PfYRS inhibitor
|
ML901 is a potent, specific inhibitor of P. falciparum tyrosine tRNA synthetase (PfYRS, PfTyrRS), shows potent activity against P. falciparum with IC50 of 2.0 nM. |
| PC-23599 |
ML471
PfYRS inhibitor
|
ML471 is a potent, selective reaction hijacking inhibitor of P.falciparum tyrosine tRNA synthetase (PfTyrRS, PfYRS), inhibits growth of asexual blood stage P. falciparum (3D7 strain) in a 72-h exposure assay with IC50 of 2.8 nM. |
| PC-23461 |
VCC234718
Mtb GuaB2 inhibitor
|
VCC234718 isa potent, specific small molecule inhibitor of Mtb inosine-5′-monophosphate dehydrogenase (IMPDH) GuaB2 with Ki of 100 nM, shows growth inhibitory activity against Mycobacterium tuberculosis (Mtb H37Rv, MIC90=2 uM). |
