ELQ-271

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Chemical Structure : ELQ-271

Catalog No.: PC-24761Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ELQ-271 is a potent, orally bioavailable inhibitor of T. gondii growth in vitro (IC50=0.1 nM) and is effective against acute and latent toxoplasmosis in mice, inhibits cytochrome c reduction by the T. gondii cytochrome bc(1) complex.
ELQ-271 has ED(50) value of 0.14 mg/kg when administered orally to mice with acute toxoplasmosis.
ELQ-271 is highly active against the cyst form of T. gondii in mice at low doses, reducing cyst burden by 76-88% after 16 d of treatment.

Physicochemical Properties

M.Wt	361.32
Formula	C19H14F3NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)pyridin-4(1H)-one

References

1. Doggett JS, et al. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15936-41.

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ELQ-271

Biological Activity

Physicochemical Properties

References

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