Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Antibiotics and Antivirals-Parasite-DMU759
DMU759

Chemical Structure : DMU759

CAS No.: 3052352-22-1

Add to Favorites

DMU759 (DMU-759)

Catalog No.: PC-24979Not For Human Use, Lab Use Only.

DMU759 is a specific inhibitor of T. cruzi lysyl-tRNA synthetase 1 (TcKRS1) with IC50 of 15 nM, demonstrates potent activity against T. cruzi (Sylvio X10/7A1strain) with EC50 of 14 nM.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DMU759 is a specific inhibitor of T. cruzi lysyl-tRNA synthetase 1 (TcKRS1) with IC50 of 15 nM, demonstrates potent activity against T. cruzi (Sylvio X10/7A1strain) with EC50 of 14 nM.
DMU759 is pan-active against all kinetoplastid parasites.
DMU759 binds to the ATP-binding pocket of KRS1.
DMU759 is not a potent inhibitor of the human ortholog of KRS1 with IC50 of >7000 nM.
DMU759 (50 mg/kg, twice a day) is capable of reducing parasitemia by up to 81% in mouse model of acute T. cruzi infection.

Physicochemical Properties

M.Wt 327.37
Formula C15H16F3N3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-(cyclohexylthio)-5,6,8-trifluoro-2-methylquinazolin-4-amine

References

1. Tulloch LB, et al. Sci Transl Med. 2025 Jul 9;17(806):eadu4564.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: