| Cat. No. |
Product Name |
Information |
| PC-21553 |
TDI-8304
Pf20S inhibitor
|
TDI-8304 is a highly selective, macrocyclic peptide inhibitor of malaria parasite Plasmodium falciparum proteasome (Pf20S) with IC50 of 0.06 uM, shows high potency against P. falciparum strain Pf 3D7 (EC50=0.009 uM). |
| PC-21550 |
DNDI-6174
Cyt bc1 inhibitor
|
DNDI-6174 is a highly potent inhibitor of Leishmania cytochrome bc1 complex activity, shows broad activity against a panel of representative visceral leishmaniasis clinical isolates from various sources (EC50=10-360 nM). |
| PC-21022 |
OSM-S-106
PfAsnRS inhibitor
|
OSM-S-106 is a reaction hijacking inhibitor of Plasmodium falciparum asparagine tRNA synthetase (PfAsnRS), inhibits the 3D7 line of P. falciparum with IC50 of 58 nM. |
| PC-20587 |
ML276
PfG6PDH inhibitor
|
ML276 (ML 276) is a potent, selective inhibitor of Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PDH) with IC50 of 889 nM, with no activity against human G6PD. |
| PC-20586 |
ML304
PfG6PDH inhibitor
|
ML304 (ML 304) is a potent, selective inhibitor of Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PDH) with IC50 of 190 nM, with no activity against human G6PD (IC50=80 uM). |
| PC-20446 |
Nemacol-1
VAChT inhibitor
|
Nemacol-1 is a small molecule inhibitor of C. elegans vesicular acetylcholine transporter (VAChT), demonstrates nematode-selective activity (C. elegans, EC50=7.1 uM). |
| PC-20297 |
P4Q-391
P.f Cyt bc1 inhibitor
|
P4Q-391 is an antimalarial agent with selective inhibition of the parasite's coenzyme Q cycle, inhibits mitochondrial cytochrome bc1 complex (Cyt bc1). |
| PC-20296 |
ELQ-300
P.f Cyt bc1 inhibitor
|
ELQ-300 (ELQ300) is a potent, selective inhibitor of P. falciparummitochondrial cytochrome bc1 complex with IC50 of 0.56 nM. |
| PC-20295 |
ELQ-331
P.f Cyt bc1 inhibitor
|
ELQ-331 (ELQ331) is an alkoxycarbonate prodrug of antimalarial compound ELQ-300 (P. falciparum cytochrome bc1 complex inhibitor), shows P. falciparum IC50 of 6 nM. |
| PC-20294 |
GSK932121
P.f Cyt bc1 inhibitor
|
GSK932121 is a potent, selective inhibitor of P. falciparum cytochrome bc1 with IC50 of 7 nM, binds to Qi site of cytochrome bc1 and shows potent antimalarial activity in vitro and in vivo. |
| PC-20293 |
GW844520
P.f Cyt bc1 inhibitor
|
GW844520 is a potent, selective inhibitor of P. falciparum cytochrome bc1 with IC50 of 2 nM, binds to Qi site of cytochrome bc1 and shows potent antimalarial activity. |
| PC-20289 |
WJM228
P.f Cyt bc1 inhibitor
|
WJM228 (WJM-228) is a potent selective inhibitor of P. falciparum cytochrome bc1, targets the Qo site of cytochrome b (cyt b), shows potent parasite activity against P. falciparum 3D7 with EC50 of 19 nM. |
