| Cat. No. |
Product Name |
Information |
| PC-20261 |
DSM705
DHODH inhibitor
|
DSM705 (DSM 705) is a potent, highly selective, long-duration and orally bioavailable malaria DHODH inhibitor with IC50 of 95 nM (PfDHODH). |
| PC-49850 |
DSM186
AbDHODH inhibitor
|
DSM186 (DSM 186) is a high potent A. baumannii DHODH (AbDHODH) inhibitor with IC50 of 28 nM, has MIC <1 ug/mL against geographically diverse A. baumannii strains, including meropenem-resistant isolates. |
| PC-49849 |
DSM161
AbDHODH inhibitor
|
DSM161 (DSM 161) is a high potent A. baumannii DHODH (AbDHODH) inhibitor, has MIC <1 ug/mL against geographically diverse A. baumannii strains, including meropenem-resistant isolates. |
| PC-49833 |
WEHI-600
Pf PMX inhibitor
|
WEHI-600 is a potent, small molecule inhibitor of the aspartic proteases Plasmepsin X (PMX) with IC50 of 3 nM, possess potent anti-parasitic activity (P. falciparum parasite, IC50=7 nM). |
| PC-49832 |
WEHI-601
Pf PMX inhibitor
|
WEHI-601 is a potent, small molecule inhibitor of the aspartic proteases Plasmepsin X (PMX) with IC50 of 5 nM, possess potent anti-parasitic activity (P. falciparum parasite, IC50=9 nM). |
| PC-49831 |
CWHM-117
Pf PM-II inhibitor
|
CWHM-117 is potent nanomolar inhibitor of the Plasmodium aspartic proteases PM-II and PM-IV with IC50 of 4 and 15 nM respectively, exhibits IC50 of 463 nM in the Pf 3D7 infected RBC assays. |
| PC-49830 |
TCMDC-136879
Antimalarial
|
TCMDC-136879 is a cyclic acyl guanidine compound with antimalarial activity. |
| PC-49829 |
WM382
Pf PMX inhibitor
|
WM382 (WM-382) is a potent, specific dual inhibitor of the aspartic proteases Plasmepsin IX and X (PMIX and PMX) with IC50 of 0.06 nM (PMX), blocks multiple stages of the Plasmodium life cycle. |
| PC-49827 |
UCB7362
Pf PMX inhibitor
|
UCB7362 (UCB 7362) is a potent, selective inhibitor of malaria parasite plasmepsin X (PMX) with IC50 of 7 nM for P. falciparum (Pf PMX) and plasmodium vivax (Pv PMX), SPR Kd of 5.5 nM, also inhibits PMIX with IC50 of 142 nM. |
| PC-49610 |
Halofuginone
PfcPRS inhibitor
|
Halofuginone (RU-19110) is a small molecule febrifugine analog targeting the Plasmodium falciparum prolyl-tRNA synthetase (PfcPRS, Ki=18.3 nM), inhibits wildtype Dd2 strain of P. falciparum with EC50 of 0.5 nM. |
| PC-49609 |
Febrifugine
PfcPRS inhibitor
|
Febrifugine is a quinazolinone alkaloid for treating malaria-induced fever for about 2000 years, targets the Plasmodium falciparum prolyl-tRNA synthetase (PfcPRS). |
| PC-49608 |
Halofuginol
PfcPRS inhibitor
|
Halofuginol (MAZ1805) is a halofuginone analog targeting the Plasmodium falciparum prolyl-tRNA synthetase (PfcPRS, Ki=71.1 nM), is highly active against both liver and asexual blood stages of the malaria parasite (EC50=5.8 nM, P. falciparum 3D7 parasite strain). |
