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Chemical Structure : P4Q-391
Catalog No.: PC-20297Not For Human Use, Lab Use Only.
P4Q-391 is an antimalarial agent with selective inhibition of the parasite's coenzyme Q cycle, inhibits mitochondrial cytochrome bc1 complex (Cyt bc1).
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P4Q-391 is an antimalarial agent with selective inhibition of the parasite's coenzyme Q cycle, inhibits mitochondrial cytochrome bc1 complex (Cyt bc1).
P4Q-391 displays high selectivity (>10,000-fold) over human Cyt bc1.
P4Q-391 shows great selective activity against all stages of the parasite's life cycle.
P4Q-391 inhibits multidrug resistant malarial strains W2 and TM90-C2B with IC50 of 3.7 and 15 nM, respectively.
P4Q-391 is highly active against exoerythrocytic stages of P. berghei and P. cynomolgi liver schizonts.
| M.Wt | 493.84 | |
| Formula | C24H16ClF4NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cross RM, et al, J. Med. Chem. 2014, 57, 8860.
2. Nilsen A, et al, Sci. Transl. Med. 2013, 5, 177re37.
3. Fabian Brockmeyer, et al. Chimia (Aarau). 2017 Apr 26;71(4):213-219.
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