Catalog No.: PC-20295Not For Human Use, Lab Use Only.
ELQ-331 (ELQ331) is an alkoxycarbonate prodrug of antimalarial compound ELQ-300 (P. falciparum cytochrome bc1 complex inhibitor), shows P. falciparum IC50 of 6 nM.
ELQ-331 (ELQ331) is an alkoxycarbonate prodrug of antimalarial compound ELQ-300 (P. falciparum cytochrome bc1 complex inhibitor), shows P. falciparum IC50 of 6 nM.
ELQ-331 is likely converted to ELQ-300 via esterase activity in parasite-infected red blood cells.
ELQ-331 is equally as effective as ELQ-300 against P. falciparum-infected red blood cells (P. falciparum IC50=6 nM).
ELQ-331 prevents parasite recrudescence at an oral dose of 1 mg/kg/day.
ELQ-331 is a prodrug that appears to be readily absorbed following oral administration and is converted to ELQ-300 by host esterases to achieve superior bloodstream exposure and prophylactic as well as curative efficacy.
