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Chemical Structure : ELQ-331
Catalog No.: PC-20295Not For Human Use, Lab Use Only.
ELQ-331 (ELQ331) is an alkoxycarbonate prodrug of antimalarial compound ELQ-300 (P. falciparum cytochrome bc1 complex inhibitor), shows P. falciparum IC50 of 6 nM.
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ELQ-331 (ELQ331) is an alkoxycarbonate prodrug of antimalarial compound ELQ-300 (P. falciparum cytochrome bc1 complex inhibitor), shows P. falciparum IC50 of 6 nM.
ELQ-331 is likely converted to ELQ-300 via esterase activity in parasite-infected red blood cells.
ELQ-331 is equally as effective as ELQ-300 against P. falciparum-infected red blood cells (P. falciparum IC50=6 nM).
ELQ-331 prevents parasite recrudescence at an oral dose of 1 mg/kg/day.
ELQ-331 is a prodrug that appears to be readily absorbed following oral administration and is converted to ELQ-300 by host esterases to achieve superior bloodstream exposure and prophylactic as well as curative efficacy.
| M.Wt | 577.94 | |
| Formula | C28H23ClF3NO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Frueh L, et al. ACS Infect Dis. 2017 Oct 13;3(10):728-735.
2. Smilkstein MJ, et al. Malar J. 2019 Aug 27;18(1):291.
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