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WJM228

Chemical Structure : WJM228

CAS No.: 2920880-95-9

WJM228 (WJM-228)

Catalog No.: PC-20289Not For Human Use, Lab Use Only.

WJM228 (WJM-228) is a potent selective inhibitor of P. falciparum cytochrome bc1, targets the Qo site of cytochrome b (cyt b), shows potent parasite activity against P. falciparum 3D7 with EC50 of 19 nM.

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    Biological Activity

    WJM228 (WJM-228) is a potent selective inhibitor of P. falciparum cytochrome bc1, targets the Qo site of cytochrome b (cyt b), shows potent parasite activity against P. falciparum 3D7 with EC50 of 19 nM.

    Physicochemical Properties

    M.Wt 370.43
    Formula C20H23FN4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-ethyl-6-fluoro-3-(3-methyl-1,2,4-oxadiazol-5-yl)-7-(4-methylpiperidin-1-yl)quinolin-4(1H)-one

    References

    1. William Nguyen, et al. ACS Infect Dis. 2023 Mar 10;9(3):668-691.

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